Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications
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Wiley Open Access
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| Natura: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867014544391405569 |
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| author | Lucas Henrique Junges Marcelo Müller‐Santos |
| author_facet | Lucas Henrique Junges Marcelo Müller‐Santos Lucas Henrique Junges Marcelo Müller‐Santos |
| collection | Wiley Open Access |
| contents | Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications Lucas Henrique Junges Marcelo Müller‐Santos Biotechnology Progress AbstractTryptamines play diverse roles as neurotransmitters and psychoactive compounds found in various organisms. Psilocybin, a notable tryptamine, has garnered attention for its therapeutic potential in treating mental health disorders like depression and anxiety. Despite its promising applications, current extraction methods for psilocybin are labor‐intensive and economically limiting. We suggest biocatalysis as a sustainable alternative, leveraging enzymes to synthesize psilocybin and other tryptamines efficiently. By elucidating psilocybin biosynthesis pathways, researchers aim to advance synthetic methodologies and industrial applications. This review underscores the transformative potential of biocatalysis in enhancing our understanding of tryptamine biosynthesis and facilitating the production of high‐purity psilocybin and other tryptamines for therapeutic and research use. 10.1002/btpr.3513 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/btpr.3513 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_btpr_3513 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications Lucas Henrique Junges Marcelo Müller‐Santos Biotechnology Progress Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications Lucas Henrique Junges Marcelo Müller‐Santos Biotechnology Progress AbstractTryptamines play diverse roles as neurotransmitters and psychoactive compounds found in various organisms. Psilocybin, a notable tryptamine, has garnered attention for its therapeutic potential in treating mental health disorders like depression and anxiety. Despite its promising applications, current extraction methods for psilocybin are labor‐intensive and economically limiting. We suggest biocatalysis as a sustainable alternative, leveraging enzymes to synthesize psilocybin and other tryptamines efficiently. By elucidating psilocybin biosynthesis pathways, researchers aim to advance synthetic methodologies and industrial applications. This review underscores the transformative potential of biocatalysis in enhancing our understanding of tryptamine biosynthesis and facilitating the production of high‐purity psilocybin and other tryptamines for therapeutic and research use. 10.1002/btpr.3513 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications |
| topic | Biotechnology Progress |
| url | https://aiche.onlinelibrary.wiley.com/doi/10.1002/btpr.3513 |