Buchumschlag

Enhancing real‐time cell culture process monitoring through the integration of advanced machine learning techniques: A comparative analysis of Raman and capacitance spectroscopies

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Feng Xu, Nuno Pinto, George Zhou, Sanjeev Ahuja
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Biotechnology Progress
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Improved methodology for direct monitoring of large‐scale manufacturing cell culture using Raman spectroscopy data from process development
von: Hadi El Radi, et al.
Veröffentlicht: (2026)

Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor
von: Amir M. Behdani, et al.
Veröffentlicht: (2024)

Synthetic modeling: A cell‐free approach for faster implementation of Raman spectroscopy in cell culture
von: Célia Sanchez, et al.
Veröffentlicht: (2025)

Continuous glucose feedback control using Raman spectroscopy and deep learning models for biopharmaceutical processes
von: Mohammad Rashedi, et al.
Veröffentlicht: (2025)

Innovative methodology for flexible monitoring of various bioprocesses by using pre‐existing Raman data coupled with automated transfer learning technique
von: Adèle Schini, et al.
Veröffentlicht: (2026)

Raman spectroscopy and one‐dimensional convolutional neural network modeling as a real‐time monitoring tool for in vitro transaminase‐catalyzed synthesis of a pharmaceutically relevant amine precursor
von: Julie Østerby Madsen, et al.
Veröffentlicht: (2024)

Machine learning‐assisted clone selection for intensified cell culture processes
von: Nicolas Wolnick, et al.
Veröffentlicht: (2026)

Enhanced cell‐specific productivity through delayed supplementation of antioxidants in intensified processes
von: Suyang Wu, et al.
Veröffentlicht: (2025)

High‐sensitivity real‐time monitoring of pH and respiration activity unveils metabolic dynamics in shake flask cultures
von: Burak Sarikaya, et al.
Veröffentlicht: (2024)

Effect of cell retention techniques in Komagataella phaffii lab‐scale continuous processes
von: Marina Y. Linova, et al.
Veröffentlicht: (2025)

Hybrid modeling for in silico optimization of a dynamic perfusion cell culture process
von: Piyush Agarwal, et al.
Veröffentlicht: (2024)

Impact of bioreactor process parameters and yeast biomass on Raman spectra
von: Maarten Klaverdijk, et al.
Veröffentlicht: (2025)

An efficient and robust strategy for developing cell lines through targeted integration
von: Duncan McVey, et al.
Veröffentlicht: (2026)

Rapid development of a transferable R aman model using high‐throughput cell culture for monitoring monoclonal antibody titer
von: Alexandra Umprecht, et al.
Veröffentlicht: (2026)

A practical framework for clone selection, media‐feed screening, and upstream process parameter optimization for a mAb CHO cell culture process
von: Shreya Shah, et al.
Veröffentlicht: (2026)

Utilizing C ole– C ole parameters for in‐line feedback: Cell culture process adjustments based on cell health
von: Nithya Krishnan, et al.
Veröffentlicht: (2025)

Use of live digital twin (shadow) soft sensor to monitor membrane degradation in continuous manufacturing single pass tangential flow filtration
von: Robert Taylor, et al.
Veröffentlicht: (2025)

Artificial intelligence and machine learning‐assisted digital applications for biopharmaceutical manufacturing
von: Shyam Panjwani, et al.
Veröffentlicht: (2025)

Characterization of apoptosis in fed‐batch cultures highlights the impact of timely process intervention on improving recombinant protein productivity
von: Misaal Patel, et al.
Veröffentlicht: (2026)

Host cell proteins in monoclonal antibody processing: Control, detection, and removal
von: Takao Ito, et al.
Veröffentlicht: (2024)

Just passing through: Deploying aquaporins in microbial cell factories
von: Liam Richard Jenkins Sánchez, et al.
Veröffentlicht: (2024)

Tangential flow filtration‐facilitated purification of human red blood cell membrane fragments and its preferential use in removing unencapsulated material from resealed red blood cell ghosts compared to centrifugation
von: Xiangming Gu, et al.
Veröffentlicht: (2024)

Implementation of mDoE ‐methods to a microcarrier‐based expansion processes for mesenchymal stem cells
von: Kim B. Kuchemüller, et al.
Veröffentlicht: (2024)

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase
von: Nicolas Marx, et al.
Veröffentlicht: (2025)

A digital shadow of CAR T cell expansion in a perfusion bioreactor: Informing optimal harvest times for autologous cell therapy
von: Joseph R. Egan, et al.
Veröffentlicht: (2025)

Automation of an integrated micro‐scale platform for monoclonal antibody process development by incorporation of a depth filter mimic
von: Paras Sharma, et al.
Veröffentlicht: (2025)

Enhancing the performance of an in vitro RNA biosensor through iterative design of experiments
von: Rochelle Aw, et al.
Veröffentlicht: (2025)

Process intensification of the baculovirus expression vector system using a perfusion process with a low multiplicity of infection at high cell concentrations
von: Jort J. Altenburg, et al.
Veröffentlicht: (2025)

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors
von: Lucas Lemire, et al.
Veröffentlicht: (2025)

Strategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation
von: Cynthia Lam, et al.
Veröffentlicht: (2024)

A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines
von: Yu‐Chieh Lin, et al.
Veröffentlicht: (2025)

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach
von: Peter Amaya, et al.
Veröffentlicht: (2025)

Enhancing cell separation in a hybrid spiral dielectrophoretic microchannel: Numerical insights and optimal operating conditions
von: Mohammed Raihan Uddin, et al.
Veröffentlicht: (2024)

Enhancing cryopreservation of human induced pluripotent stem cells: Bottom‐up versus conventional freezing geometry
von: Fernando Teodoro, et al.
Veröffentlicht: (2025)

Kinetic and equilibrium analysis of electrochemical Aptasensing for real‐time detection of Staphylococcus aureus in food substances
von: Shokoufeh Soleimani, et al.
Veröffentlicht: (2025)

Design of experiments‐guided membrane capture facilitates integration of continuous virus inactivation using Phi6 as a surrogate virus in an intensified downstream process
von: Mario Grünberg, et al.
Veröffentlicht: (2026)

Primary clarification of mammalian cell culture fluid using enhanced sedimentation on inclined surfaces inside the single‐use disposable Sudhin BioSettler150
von: Christopher B. Glascock, et al.
Veröffentlicht: (2024)

Gene copy number, gene configuration and LC / HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines
von: Zion Lee, et al.
Veröffentlicht: (2024)

A size‐exclusion chromatography fingerprinting workflow for the development of flow‐through polishing operations for mAbs derived from continuous precipitation processes
von: Mario A. Gutierrez‐Diaz, et al.
Veröffentlicht: (2026)

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5
von: Wenjin Xi, et al.
Veröffentlicht: (2025)