| _version_ | 1867011809514356736 |
|---|---|
| author | Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan |
| author_facet | Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan |
| collection | Wiley Open Access |
| contents | Molecular Mechanisms of ARD1 in Tumors Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan Cancer Medicine ABSTRACTIntroductionArrest‐deficient protein 1 (ARD1) is an acetyltransferase that acetylates the N‐terminal amino acids and internal lysine residues of proteins. It plays a crucial role in various cellular processes. The significance of ARD1 in tumor development has become increasingly evident in recent years.MethodsThis review analyzes the regulatory role of ARD1 in tumor progression by examining its involvement in processes such as cell cycle regulation, cell proliferation, metastasis, apoptosis, and autophagy. Additionally, we discuss the expression patterns and molecular mechanisms of ARD1 in different types of cancer.ResultsElevated levels of ARD1 have been reported in several cancer types. Its increased expression is associated with various tumor characteristics, suggesting it may serve as a potential prognostic biomarker. Furthermore, ARD1 could be targeted for the development of novel cancer therapies.ConclusionUnderstanding the role of ARD1 in tumor biology provides valuable insights into potential therapeutic targets and biomarkers for cancer treatment. This review highlights the advances in ARD1‐related research and suggests that it may be a promising avenue for improving cancer prognosis and treatment strategies. 10.1002/cam4.70708 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/cam4.70708 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cam4_70708 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Molecular Mechanisms of ARD1 in Tumors Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan Cancer Medicine Molecular Mechanisms of ARD1 in Tumors Chunjiao Yu Hongtao Lei Xuefei Hou Shan Yan Cancer Medicine ABSTRACTIntroductionArrest‐deficient protein 1 (ARD1) is an acetyltransferase that acetylates the N‐terminal amino acids and internal lysine residues of proteins. It plays a crucial role in various cellular processes. The significance of ARD1 in tumor development has become increasingly evident in recent years.MethodsThis review analyzes the regulatory role of ARD1 in tumor progression by examining its involvement in processes such as cell cycle regulation, cell proliferation, metastasis, apoptosis, and autophagy. Additionally, we discuss the expression patterns and molecular mechanisms of ARD1 in different types of cancer.ResultsElevated levels of ARD1 have been reported in several cancer types. Its increased expression is associated with various tumor characteristics, suggesting it may serve as a potential prognostic biomarker. Furthermore, ARD1 could be targeted for the development of novel cancer therapies.ConclusionUnderstanding the role of ARD1 in tumor biology provides valuable insights into potential therapeutic targets and biomarkers for cancer treatment. This review highlights the advances in ARD1‐related research and suggests that it may be a promising avenue for improving cancer prognosis and treatment strategies. 10.1002/cam4.70708 http://creativecommons.org/licenses/by/4.0/ |
| title | Molecular Mechanisms of ARD1 in Tumors |
| topic | Cancer Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1002/cam4.70708 |