Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties
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Wiley
2025
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| author | Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel |
| author_facet | Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel |
| collection | Wiley Open Access |
| contents | Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel Cell Biochemistry and Function ABSTRACTThe present study aimed to optimize a mouth‐dissolving film (MDF) made from Pongamia pinnata stem bark extract to increase patient compliance and accelerate oral disease therapy. Several stem bark extracts were prepared, and karanjin was used as an herbal marker for the extracts. The ethanolic extract showed the maximum yield (12.10% ± 0.09%) and cytotoxic activity against human oral cancer (KB 3‐1) and embryonic kidney cell lines. The MDF formulation was focused on incorporating a fixed amount of the extract and varying concentrations of HPMC E5 polymer, along with evaluating the performance of plasticizers like PEG 400 and propylene glycol (PG). An optimized formulation was determined based on disintegration time, wetting time, and folding endurance. The formulation consisted of HPMC E5 as a film‐forming polymer, PG as a superior plasticizer, ascorbic acid as an antioxidant, and other ingredients contributing to solubility, dispersion, sweetening, and appearance. High‐performance thin‐layer chromatography‐mass spectrometry analysis confirmed higher levels of karanjin in the optimized formulation, ensuring its successful incorporation and stability. Taste masking evaluations indicate a favorable taste profile and a high potential for patient compliance. The stability study displayed no significant changes in the physical characteristics of the film, affirming its stability and quality. In conclusion, the developed herbal‐based optimized MDF presents a promising drug delivery system, offering enhanced patient compliance, taste masking, and stability. The MDF holds great potential for effective treatment and management of oral diseases, providing convenience and improved therapeutic outcomes. 10.1002/cbf.70049 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/cbf.70049 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cbf_70049 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel Cell Biochemistry and Function Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties Devang Prajapati Masuma Hakim Margi Patel Mohammad Javed Ansari Saleh Alfarraj Sanjay Chauhan Vaibhav Bhatt Virendra Kumar Yadav Dipak Kumar Sahoo Kashyap Thummar Ashish Patel Cell Biochemistry and Function ABSTRACTThe present study aimed to optimize a mouth‐dissolving film (MDF) made from Pongamia pinnata stem bark extract to increase patient compliance and accelerate oral disease therapy. Several stem bark extracts were prepared, and karanjin was used as an herbal marker for the extracts. The ethanolic extract showed the maximum yield (12.10% ± 0.09%) and cytotoxic activity against human oral cancer (KB 3‐1) and embryonic kidney cell lines. The MDF formulation was focused on incorporating a fixed amount of the extract and varying concentrations of HPMC E5 polymer, along with evaluating the performance of plasticizers like PEG 400 and propylene glycol (PG). An optimized formulation was determined based on disintegration time, wetting time, and folding endurance. The formulation consisted of HPMC E5 as a film‐forming polymer, PG as a superior plasticizer, ascorbic acid as an antioxidant, and other ingredients contributing to solubility, dispersion, sweetening, and appearance. High‐performance thin‐layer chromatography‐mass spectrometry analysis confirmed higher levels of karanjin in the optimized formulation, ensuring its successful incorporation and stability. Taste masking evaluations indicate a favorable taste profile and a high potential for patient compliance. The stability study displayed no significant changes in the physical characteristics of the film, affirming its stability and quality. In conclusion, the developed herbal‐based optimized MDF presents a promising drug delivery system, offering enhanced patient compliance, taste masking, and stability. The MDF holds great potential for effective treatment and management of oral diseases, providing convenience and improved therapeutic outcomes. 10.1002/cbf.70049 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties |
| topic | Cell Biochemistry and Function |
| url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.70049 |