Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS‐Induced Colitis by Enhancing Goblet Cell Differentiation
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| Format: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867013356788908033 |
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| author | Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li |
| author_facet | Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li |
| collection | Wiley Open Access |
| contents | Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS‐Induced Colitis by Enhancing Goblet Cell Differentiation Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li Cell Biology International ABSTRACT Dysregulation of epoxide hydrolase 2 (EPHX2) is associated with the pathogenesis of various diseases. However, the functional role of EPHX2 in ulcerative colitis remains unclear. In this study, we demonstrate that EPHX2 plays a critical role in driving the pathological breakdown of barrier integrity in a colitis model. Pharmacological inhibition of EPHX2 significantly ameliorated Dextran Sulfate Sodium (DSS)‐induced colitis. Notably, conditional knockout of EPHX2 in intestinal epithelial cells (IECs) conferred protection against colitis‐associated mucosal damage. Moreover, EPHX2 deletion in IECs led to increased Muc2 expression and a higher number of goblet cells by promoting goblet cell differentiation, while the expression levels of tight junction proteins (ZO‐1, occludin, and claudin‐1) remained unchanged. These findings identify a previously unrecognized role of EPHX2 in IECs and suggest that targeting EPHX2 may represent a promising therapeutic strategy for ulcerative colitis. 10.1002/cbin.70100 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/cbin.70100 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cbin_70100 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS‐Induced Colitis by Enhancing Goblet Cell Differentiation Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li Cell Biology International Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS‐Induced Colitis by Enhancing Goblet Cell Differentiation Jiuheng Yin Duoli Zhang Hongxiang Zeng Ting Wang Xi Li Cell Biology International ABSTRACT Dysregulation of epoxide hydrolase 2 (EPHX2) is associated with the pathogenesis of various diseases. However, the functional role of EPHX2 in ulcerative colitis remains unclear. In this study, we demonstrate that EPHX2 plays a critical role in driving the pathological breakdown of barrier integrity in a colitis model. Pharmacological inhibition of EPHX2 significantly ameliorated Dextran Sulfate Sodium (DSS)‐induced colitis. Notably, conditional knockout of EPHX2 in intestinal epithelial cells (IECs) conferred protection against colitis‐associated mucosal damage. Moreover, EPHX2 deletion in IECs led to increased Muc2 expression and a higher number of goblet cells by promoting goblet cell differentiation, while the expression levels of tight junction proteins (ZO‐1, occludin, and claudin‐1) remained unchanged. These findings identify a previously unrecognized role of EPHX2 in IECs and suggest that targeting EPHX2 may represent a promising therapeutic strategy for ulcerative colitis. 10.1002/cbin.70100 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS‐Induced Colitis by Enhancing Goblet Cell Differentiation |
| topic | Cell Biology International |
| url | https://onlinelibrary.wiley.com/doi/10.1002/cbin.70100 |