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| Format: | Artículo Open Access |
|---|---|
| Published: |
Wiley
2024
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202490215 |
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Table of Contents:
- Inside Back Cover Chinese Journal of Chemistry Programable peptide nucleic acid (PNA) probes assisted DNA variants detection method demonstrates exceptional sensitivity and efficiency in detecting low‐frequency mutations. We presented a computational method for calculating the stacking energy of PNA and DNA hybrids, leveraging nearest neighbor parameters. Utilizing this computational framework, we designed PNA probes, which improve amplification efficiency by more than 10‐fold and detect mutations as low as 0.5% variant allele frequency. More details are discussed in the article by Song et al. on pages 2572—2580.image 10.1002/cjoc.202490215 http://onlinelibrary.wiley.com/termsAndConditions#vor