Image de couverture de livre

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

Fuente: Wiley Open Access

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh
Format:	Artículo Open Access
Publié:	Wiley 2025
Sujets:	ChemMedChem
Accès en ligne:	Acceder al recurso
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor
par: Alexander Dömling, et autres
Publié: (2025)

Recent Advances of Quinoline‐Based Small Molecules as Kinase Inhibitors (2020–2024)
par: Sara Sultan, et autres
Publié: (2025)

Small‐Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells
par: Chao Wang, et autres
Publié: (2024)

Small Molecule Kinase Inhibitors with In Vitro β‐Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning
par: Jessica L. Thibaud, et autres
Publié: (2026)

Research Progress and Clinical Translation Challenges of Small‐Molecule Inhibitors Targeting PD‐L1
par: Liang Qian, et autres
Publié: (2026)

Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors
par: Alisa Heuser, et autres
Publié: (2024)

Small‐Molecule Inhibitors Targeting PD‐1/PD‐L1 in Colorectal Cancer: Mechanisms, Challenges, and Clinical Prospects
par: Jianwei Wang, et autres
Publié: (2025)

Small‐Molecule Fluorescent Probes for Butyrylcholinesterase
par: Zibo Lin, et autres
Publié: (2025)

Design, Synthesis, and Biological Evaluation of Small‐Molecule PD‐1/PD‐L1 Inhibitors Bearing a Rigid Benz[d]oxazole Skeleton
par: Bo Wei, et autres
Publié: (2026)

Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein‐Protein Interaction
par: Robert Obermann, et autres
Publié: (2024)

Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation
par: Jinmin Miao, et autres
Publié: (2024)

Developing Dynamic Structure‐Based Pharmacophore and ML‐Trained QSAR Models for the Discovery of Novel Resistance‐Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis
par: Ehsan Sayyah, et autres
Publié: (2024)

Design and Evaluation of Tyrosine‐Rich Antimicrobial Peptides With Quadruple Repeating Units
par: Heiya Na, et autres
Publié: (2026)

Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics
par: Nitesh Sanghai, et autres
Publié: (2024)

Small Molecule‐Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs
par: Jingjing Zhang, et autres
Publié: (2024)

Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges
par: Fabio Francavilla, et autres
Publié: (2024)

Signaling Pathways and Promising Small‐Molecule Therapeutic Agents for Ischemic Stroke
par: Debasis Das, et autres
Publié: (2025)

Selenocyanate‐Containing Molecules as Trypanosoma cruzi Inhibitors: Impact of Regioisomerism, Conformational Restriction, and Second‐Ring Substitution
par: Hugo S. Steingrüber, et autres
Publié: (2025)

Exploring Small‐Molecule Modulators of Precursor miRNA Processing Associated With Glycolysis
par: Miho Fujiki, et autres
Publié: (2026)

Discovery of ICOS‐Targeted Small Molecules Using Affinity Selection Mass Spectrometry Screening
par: Longfei Zhang, et autres
Publié: (2024)

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β ‐Hematin Formation from Areas of Enrichment
par: Jessica L. Thibaud, et autres
Publié: (2026)

Structure‐Based Virtual Screening Identifies TREM2‐Targeted Small Molecules that Enhance Microglial Phagocytosis
par: Sungwoo Cho, et autres
Publié: (2026)

A Facile Protocol for C(sp 2 )–C(sp 3 ) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
par: Anita Maksutova, et autres
Publié: (2025)

Discovery of Galactopyranose‐1‐carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin‐3 Inhibitors
par: Cornelia Zumbrunn, et autres
Publié: (2025)

Small‐Molecule Sarco/Endoplasmic Reticulum Ca 2+ ‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms
par: Carlos Cruz‐Cortés, et autres
Publié: (2025)

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi
par: Siyao Chen, et autres
Publié: (2026)

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
par: Anne Robert, et autres
Publié: (2025)

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders
par: Chelsi M. Almodóvar‐Rivera, et autres
Publié: (2025)

Marine‐Inspired Spirooxindole PIM‐1 Kinase Inhibitors Endowed with Concomitant TRKA/CDK2 Inhibition for Multifaceted Non‐Small Cell Lung Cancer Apoptotic Induction
par: Refaah M. Al‐Jassas, et autres
Publié: (2025)

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
par: Elise Kaplan, et autres
Publié: (2025)

The Role of Protein Disulfide Isomerase Inhibitors in Cancer Therapy
par: Qiuying Nie, et autres
Publié: (2024)

Binding‐Site Switch for Protein Kinase CK2 Inhibitors
par: Dylan Grenier, et autres
Publié: (2025)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds
par: Nuno Martinho, et autres
Publié: (2026)

Thiazole‐Based IL‐17 Inhibitors Discovered by Scaffold Morphing
par: Juraj Velcicky, et autres
Publié: (2025)

Gram‐Scale Synthesis of an Arylsulfonamide‐Type Alkaline Phosphatase Inhibitor
par: Zsolt Rapi, et autres
Publié: (2026)

Biaryl Phosphate‐Based Inhibitors of the Transcription Factor STAT4
par: Nadiya Brovchenko, et autres
Publié: (2025)

2‐Carboxyquinoline Boronic Acids as Highly Potent KPC Inhibitors
par: Zheng Ma, et autres
Publié: (2025)

Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties
par: Elisabetta Scalia, et autres
Publié: (2024)

Structure‐Atropisomer Stability Relationship in Selective MCL‐1 Inhibitors
par: Szabolcs Sipos, et autres
Publié: (2025)

From Deep Learning to the Discovery of Promising VEGFR‐2 Inhibitors
par: Mehmet Ali Yucel, et autres
Publié: (2024)