Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology
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Wiley Open Access
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| Format: | Artículo Open Access |
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Wiley
2026
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| _version_ | 1867019480104697856 |
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| author | Giuseppe Miserocchi Egidio Beretta |
| author_facet | Giuseppe Miserocchi Egidio Beretta Giuseppe Miserocchi Egidio Beretta |
| collection | Wiley Open Access |
| contents | Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology Giuseppe Miserocchi Egidio Beretta Comprehensive Physiology ABSTRACT This review outlines the physiological organization of heart–lung coupling that ensures efficient gas exchange. Subsequently, factors that compromise this efficiency are examined. The development of perturbation in lung fluid balance, originating from both capillary and alveolar sources, is discussed in detail, as it represents a frequently overlooked contributor to impaired gas exchange. Intrinsic mechanisms by which the lung resists edema formation are then presented. We provide a quantitative functional model based on physical principles to describe the diffusion–perfusion interaction in the air–blood barrier aiming to interpret several pathological conditions, including pulmonary fibrosis, lung resection, heart failure syndromes, and mechanically ventilated patients with acute hypoxemic respiratory failure (AHRF). 10.1002/cph4.70149 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/cph4.70149 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cph4_70149 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology Giuseppe Miserocchi Egidio Beretta Comprehensive Physiology Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology Giuseppe Miserocchi Egidio Beretta Comprehensive Physiology ABSTRACT This review outlines the physiological organization of heart–lung coupling that ensures efficient gas exchange. Subsequently, factors that compromise this efficiency are examined. The development of perturbation in lung fluid balance, originating from both capillary and alveolar sources, is discussed in detail, as it represents a frequently overlooked contributor to impaired gas exchange. Intrinsic mechanisms by which the lung resists edema formation are then presented. We provide a quantitative functional model based on physical principles to describe the diffusion–perfusion interaction in the air–blood barrier aiming to interpret several pathological conditions, including pulmonary fibrosis, lung resection, heart failure syndromes, and mechanically ventilated patients with acute hypoxemic respiratory failure (AHRF). 10.1002/cph4.70149 http://creativecommons.org/licenses/by/4.0/ |
| title | Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology |
| topic | Comprehensive Physiology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/cph4.70149 |