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| Auteurs principaux: | , , , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2026
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| Accès en ligne: | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.70535 |
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| _version_ | 1867015251930644480 |
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| author | Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang |
| author_facet | Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang |
| collection | Wiley Open Access |
| contents | Continuous Flow Synthesis of Spiro[fluorene‐9,9′‐Xanthene] Serving as the Organic Light Emitting Diode Emitters and Organic Semiconductors for Kilogram‐Scale Production With Flexible and Controllable Selectivity Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang ChemSusChem Continuous flow chemistry allows for the low‐cost and eco‐friendly mass production of organic semiconductors. Although spiro[fluorene‐9,9′‐xanthene] derivatives (SFXs) serve as a role of steric hindrance for the function of stability in OLED technology that has been industrialized and commercialized, it does not investigate their chemical engineering based on the “Huang‐Xie method” with continuous flow synthesis technology to achieve scalable production. Herein, we report that kilogram‐scale production with exceptional product selectivity (90% for SFX and 100% for BPF) with high throughput rates (648.48 g/h for SFX, 997.62 g/h for BPF). Compared with conventional batch processes, the continuous flow approach for SFX synthesis achieved a 25.48% reduction in raw material costs, solid waste generation by 45.79%, and a 68% shortening of production time. This technology exhibited remarkable environmental advantages, yielding an E‐factor of 1.54 kg/kg and a process mass intensity (PMI) of 2.54 kg/kg, representing 94.7% and 91.5% reductions relative to batch processes. Using an upgraded continuous flow platform, we also synthesized high‐performance optoelectronic materials SFX‐TRZ (84% yield) and BPFG (92.5% yield) from SFX and BPF precursors. This work opens continuous flow synthesis for organic semiconductors with advanced green chemistry principles. 10.1002/cssc.70535 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/cssc.70535 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cssc_70535 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Continuous Flow Synthesis of Spiro[fluorene‐9,9′‐Xanthene] Serving as the Organic Light Emitting Diode Emitters and Organic Semiconductors for Kilogram‐Scale Production With Flexible and Controllable Selectivity Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang ChemSusChem Continuous Flow Synthesis of Spiro[fluorene‐9,9′‐Xanthene] Serving as the Organic Light Emitting Diode Emitters and Organic Semiconductors for Kilogram‐Scale Production With Flexible and Controllable Selectivity Xiaoyan Li Shoujia Zhu Ying Wei Yue Li Shuangyi Li Xiao Long Xin Chen Yan Ge Fangli Wang Zheng Zhang Yang Li Hao Li Wenjing Shi Yun Deng Xinxin Han Linghai Xie Wei Huang ChemSusChem Continuous flow chemistry allows for the low‐cost and eco‐friendly mass production of organic semiconductors. Although spiro[fluorene‐9,9′‐xanthene] derivatives (SFXs) serve as a role of steric hindrance for the function of stability in OLED technology that has been industrialized and commercialized, it does not investigate their chemical engineering based on the “Huang‐Xie method” with continuous flow synthesis technology to achieve scalable production. Herein, we report that kilogram‐scale production with exceptional product selectivity (90% for SFX and 100% for BPF) with high throughput rates (648.48 g/h for SFX, 997.62 g/h for BPF). Compared with conventional batch processes, the continuous flow approach for SFX synthesis achieved a 25.48% reduction in raw material costs, solid waste generation by 45.79%, and a 68% shortening of production time. This technology exhibited remarkable environmental advantages, yielding an E‐factor of 1.54 kg/kg and a process mass intensity (PMI) of 2.54 kg/kg, representing 94.7% and 91.5% reductions relative to batch processes. Using an upgraded continuous flow platform, we also synthesized high‐performance optoelectronic materials SFX‐TRZ (84% yield) and BPFG (92.5% yield) from SFX and BPF precursors. This work opens continuous flow synthesis for organic semiconductors with advanced green chemistry principles. 10.1002/cssc.70535 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Continuous Flow Synthesis of Spiro[fluorene‐9,9′‐Xanthene] Serving as the Organic Light Emitting Diode Emitters and Organic Semiconductors for Kilogram‐Scale Production With Flexible and Controllable Selectivity |
| topic | ChemSusChem |
| url | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.70535 |