The relationship between folic acid and nonalcoholic fatty liver disease
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2024
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| author | Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian |
| author_facet | Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian |
| collection | Wiley Open Access |
| contents | The relationship between folic acid and nonalcoholic fatty liver disease Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian Clinical and Translational Discovery AbstractIn recent years, the incidence of non‐alcoholic fatty liver disease (NAFLD) has been increasing, which has become an explosive interest because of the growing impact on world health. NAFLD is the hepatic manifestation of systemic metabolic syndrome (MS), and the umbrella term that comprises a continuum of liver conditions, from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and hepatocellular carcinoma (HCC). currently, there is no pharmacological agent that is therapeutically approved for the treatment of this disease. Folic acid (FA) was one of a water‐soluble B vitamins, entirely absorbed from the diet. Numbers of clinical studies have confirmed that patients with NAFLD and insulin resistance are often accompanied by abnormal FA. We investigated the potential effects of FA on NAFLD through the metabolic pathways, DNA synthesis and methylation, oxidative stress in liver and intestinal flora. In addition, FA has an effect on HCC or other cancer. Therefore, FA might be a safe and economical potential treatment method for NAFLD. 10.1002/ctd2.274 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/ctd2.274 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ctd2_274 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The relationship between folic acid and nonalcoholic fatty liver disease Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian Clinical and Translational Discovery The relationship between folic acid and nonalcoholic fatty liver disease Bing'er Xu Xinyu Yang Xiaopeng Zhu Qiling Liu Yuying Zhang Miao Zhang Chenmin Fan Xilei Ban Guligeina Aikebaier Hua bian Clinical and Translational Discovery AbstractIn recent years, the incidence of non‐alcoholic fatty liver disease (NAFLD) has been increasing, which has become an explosive interest because of the growing impact on world health. NAFLD is the hepatic manifestation of systemic metabolic syndrome (MS), and the umbrella term that comprises a continuum of liver conditions, from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and hepatocellular carcinoma (HCC). currently, there is no pharmacological agent that is therapeutically approved for the treatment of this disease. Folic acid (FA) was one of a water‐soluble B vitamins, entirely absorbed from the diet. Numbers of clinical studies have confirmed that patients with NAFLD and insulin resistance are often accompanied by abnormal FA. We investigated the potential effects of FA on NAFLD through the metabolic pathways, DNA synthesis and methylation, oxidative stress in liver and intestinal flora. In addition, FA has an effect on HCC or other cancer. Therefore, FA might be a safe and economical potential treatment method for NAFLD. 10.1002/ctd2.274 http://creativecommons.org/licenses/by/4.0/ |
| title | The relationship between folic acid and nonalcoholic fatty liver disease |
| topic | Clinical and Translational Discovery |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ctd2.274 |