Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases
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Wiley Open Access
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| Main Authors: | , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew |
| author_facet | Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew |
| collection | Wiley Open Access |
| contents | Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew Clinical and Translational Discovery AbstractPatients with breast tumours that metastasise to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumours display altered energy production that results in enhanced autophagy. Preclinical studies have shown that genetically or pharmacologically disrupting the autophagy pathway significantly decreases the brain metastatic burden, resulting in improved animal survival and increased sensitivity to lapatinib. These findings pave the way for the development of novel strategies targeting autophagy for breast cancer patients with brain metastatic disease. 10.1002/ctd2.340 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/ctd2.340 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ctd2_340 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew Clinical and Translational Discovery Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases Steffan T. Nawrocki Claudia M. Espitia Maria Janina Carrera Espinoza Madison E. Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S. Carew Clinical and Translational Discovery AbstractPatients with breast tumours that metastasise to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumours display altered energy production that results in enhanced autophagy. Preclinical studies have shown that genetically or pharmacologically disrupting the autophagy pathway significantly decreases the brain metastatic burden, resulting in improved animal survival and increased sensitivity to lapatinib. These findings pave the way for the development of novel strategies targeting autophagy for breast cancer patients with brain metastatic disease. 10.1002/ctd2.340 http://creativecommons.org/licenses/by/4.0/ |
| title | Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases |
| topic | Clinical and Translational Discovery |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ctd2.340 |