Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren |
| author_facet | Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren |
| collection | Wiley Open Access |
| contents | Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren Clinical & Translational Immunology AbstractObjectivesIncreasing evidence suggests that Fc‐mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS‐CoV‐2. However, limited data are available on the potential differences in the development, heterogeneity and durability of these responses in children compared to adults.MethodsHere, we assessed the development of spike S1‐specific serum antibody‐dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and natural killer cell activation (ADNKA), alongside specific antibody binding concentrations (IgG, IgA and IgM) and IgG avidity in healthy adults (n = 38, 18–56 years) and children (n = 21, 5–16 years) following primary SARS‐CoV‐2 infection, with a 10‐month longitudinal follow‐up. Differences between groups were assessed using a nonparametric Kruskal–Wallis test with Dunn's multiple comparisons test.ResultsWe found similar (functional) antibody responses in children compared to adults, with a tendency for increased durability in children, which was statistically significant for ADCD (P < 0.05). While ADNKA was strongly reduced in both adults (P < 0.001) and children (P < 0.05) at the latest time point, ADCP remained relatively stable over time, possibly relating to an increase in avidity of the spike‐specific antibodies (P < 0.001). Finally, the ADNKA capacity relative to antibody concentration appeared to decrease over time in both children and adults.ConclusionIn conclusion, our data provide novel insights into the development of SARS‐CoV‐2‐specific antibody Fc‐mediated effector functions in children and adults. An increased understanding of these characteristics in specific age populations is valuable for the future design of novel and improved vaccination strategies for respiratory viruses such as SARS‐CoV‐2. 10.1002/cti2.1521 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1002/cti2.1521 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_cti2_1521 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren Clinical & Translational Immunology Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns Anne T Gelderloos Anke J Lakerveld Rutger M Schepp Mioara Alina Nicolaie Josine van Beek Lisa Beckers Robert S van Binnendijk Nynke Y Rots Puck B van Kasteren Clinical & Translational Immunology AbstractObjectivesIncreasing evidence suggests that Fc‐mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS‐CoV‐2. However, limited data are available on the potential differences in the development, heterogeneity and durability of these responses in children compared to adults.MethodsHere, we assessed the development of spike S1‐specific serum antibody‐dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and natural killer cell activation (ADNKA), alongside specific antibody binding concentrations (IgG, IgA and IgM) and IgG avidity in healthy adults (n = 38, 18–56 years) and children (n = 21, 5–16 years) following primary SARS‐CoV‐2 infection, with a 10‐month longitudinal follow‐up. Differences between groups were assessed using a nonparametric Kruskal–Wallis test with Dunn's multiple comparisons test.ResultsWe found similar (functional) antibody responses in children compared to adults, with a tendency for increased durability in children, which was statistically significant for ADCD (P < 0.05). While ADNKA was strongly reduced in both adults (P < 0.001) and children (P < 0.05) at the latest time point, ADCP remained relatively stable over time, possibly relating to an increase in avidity of the spike‐specific antibodies (P < 0.001). Finally, the ADNKA capacity relative to antibody concentration appeared to decrease over time in both children and adults.ConclusionIn conclusion, our data provide novel insights into the development of SARS‐CoV‐2‐specific antibody Fc‐mediated effector functions in children and adults. An increased understanding of these characteristics in specific age populations is valuable for the future design of novel and improved vaccination strategies for respiratory viruses such as SARS‐CoV‐2. 10.1002/cti2.1521 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns |
| topic | Clinical & Translational Immunology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/cti2.1521 |