Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA)
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Wiley
2024
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| author | Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro |
| author_facet | Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro |
| collection | Wiley Open Access |
| contents | Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA) Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring AbstractIntroductionGrowing interest centers on the association between circulating ketone bodies (KB) and cognitive function, notably in aging and neurodegenerative diseases.MethodsAssociations of plasma KB with incident dementia and cognitive performances were examined among Multi‐Ethnic Study of Atherosclerosis (MESA) participants. KB were measured using plasma samples collected following an overnight fasting at Exam 1 (2000–02) and detailed cognitive testing at Exam 5 (2010–2012, N = 4392), Exam 6 (2016–2018, N = 1838), and in MESA‐MIND (2019–2021, N = 2060).ResultsOver 16.7 years, a doubling of total KB was associated with a greater risk of incident dementia (hazard ratio [HR]: 1.14 [1.04–1.29]). Higher total KB was associated with worse cognitive performance in the Digit Span test at exam 5 [β: −0.30 (−0.47, −0.14)]. We also found that a higher KB was associated with greater functional impairment and a higher Quick Dementia Rating Scale (QDRS) score.DiscussionIn a diverse, cardiovascular disease‐free population, elevated KB levels were associated with incident dementia and impaired cognitive performance in specific domains.Highlights A study of ketone bodies (KB) and cognitive performance and incident dementia. Nuclear magnetic resonance (NMR) spectroscopy was used to measure plasma KB at baseline. Doubling of baseline total KB was associated with higher incident dementia. Higher KB was also associated with worse performance on a test of working memory. 10.1002/dad2.70039 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1002/dad2.70039 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_dad2_70039 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA) Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA) Parag Anilkumar Chevli Christopher L. Schaich Alexis C. Wood Luqman A. TK Anurag Mehta Vardhmaan Jain Margery Connelly Suzanne Craft Elad Shemesh José A. Luchsinger Kathleen M. Hayden Bonnie Colleen Sachs Timothy M. Hughes Michael D. Shapiro Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring AbstractIntroductionGrowing interest centers on the association between circulating ketone bodies (KB) and cognitive function, notably in aging and neurodegenerative diseases.MethodsAssociations of plasma KB with incident dementia and cognitive performances were examined among Multi‐Ethnic Study of Atherosclerosis (MESA) participants. KB were measured using plasma samples collected following an overnight fasting at Exam 1 (2000–02) and detailed cognitive testing at Exam 5 (2010–2012, N = 4392), Exam 6 (2016–2018, N = 1838), and in MESA‐MIND (2019–2021, N = 2060).ResultsOver 16.7 years, a doubling of total KB was associated with a greater risk of incident dementia (hazard ratio [HR]: 1.14 [1.04–1.29]). Higher total KB was associated with worse cognitive performance in the Digit Span test at exam 5 [β: −0.30 (−0.47, −0.14)]. We also found that a higher KB was associated with greater functional impairment and a higher Quick Dementia Rating Scale (QDRS) score.DiscussionIn a diverse, cardiovascular disease‐free population, elevated KB levels were associated with incident dementia and impaired cognitive performance in specific domains.Highlights A study of ketone bodies (KB) and cognitive performance and incident dementia. Nuclear magnetic resonance (NMR) spectroscopy was used to measure plasma KB at baseline. Doubling of baseline total KB was associated with higher incident dementia. Higher KB was also associated with worse performance on a test of working memory. 10.1002/dad2.70039 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA) |
| topic | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
| url | https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70039 |