Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz |
| author_facet | Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz |
| collection | Wiley Open Access |
| contents | Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz Developmental Psychobiology AbstractOxidative stress has been identified as an important biological pathway leading to neurodevelopmental delay. However, studies assessing the effects of oxidative stress on cognitive outcomes during infancy, a critical period of neurodevelopment, are limited. Our analysis included a subset of those enrolled in the Illinois Kids Development Study (N = 144). Four oxidative stress biomarkers (8‐isoprostane‐PGF2α, 2,3‐dinor‐5,6‐dihydro‐8‐iso‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α) were measured in second and third trimesters urine and were averaged. Infant cognition was measured using a visual recognition memory task consisting of five blocks, each with one familiarization trial (two identical stimuli) and two test trials (one familiar and one novel stimulus). Outcomes measured included average run duration (a measure of information processing speed), novelty preference (a measure of recognition memory), time to reach familiarization, and shift rate (measures of attention). Linear regression was used to estimate associations between individual oxidative stress biomarkers and each outcome. Increasing 8‐isoprostane‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α were associated with a decrease in novelty preference (β = −0.02, 95% confidence interval [CI] = −0.03, 0.00; β = −0.02, 95% CI = −0.04, 0.00; β = −0.01, 95% CI = −0.02, 0.00, respectively), as well as a modest increase in shift rate. These findings suggest that oxidative stress may be associated with poorer recognition memory in early infancy. 10.1002/dev.22457 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/dev.22457 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_dev_22457 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz Developmental Psychobiology Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months Stephanie M. Eick Kaegan Ortlund Andréa Aguiar Francheska M. Merced‐Nieves Megan L. Woodbury Ginger L. Milne Susan L. Schantz Developmental Psychobiology AbstractOxidative stress has been identified as an important biological pathway leading to neurodevelopmental delay. However, studies assessing the effects of oxidative stress on cognitive outcomes during infancy, a critical period of neurodevelopment, are limited. Our analysis included a subset of those enrolled in the Illinois Kids Development Study (N = 144). Four oxidative stress biomarkers (8‐isoprostane‐PGF2α, 2,3‐dinor‐5,6‐dihydro‐8‐iso‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α) were measured in second and third trimesters urine and were averaged. Infant cognition was measured using a visual recognition memory task consisting of five blocks, each with one familiarization trial (two identical stimuli) and two test trials (one familiar and one novel stimulus). Outcomes measured included average run duration (a measure of information processing speed), novelty preference (a measure of recognition memory), time to reach familiarization, and shift rate (measures of attention). Linear regression was used to estimate associations between individual oxidative stress biomarkers and each outcome. Increasing 8‐isoprostane‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α were associated with a decrease in novelty preference (β = −0.02, 95% confidence interval [CI] = −0.03, 0.00; β = −0.02, 95% CI = −0.04, 0.00; β = −0.01, 95% CI = −0.02, 0.00, respectively), as well as a modest increase in shift rate. These findings suggest that oxidative stress may be associated with poorer recognition memory in early infancy. 10.1002/dev.22457 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months |
| topic | Developmental Psychobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/dev.22457 |