Testing detectability, attractivity, hedonic specificity, extractability, and robustness of colostrum odor—Toward an olfactory bioassay for human neonates
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal |
| author_facet | Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal |
| collection | Wiley Open Access |
| contents | Testing detectability, attractivity, hedonic specificity, extractability, and robustness of colostrum odor—Toward an olfactory bioassay for human neonates Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal Developmental Psychobiology AbstractHuman milk odor is attractive and appetitive for human newborns. Here, we studied behavioral and heart‐rate (HR) responses of 2‐day‐old neonates to the odor of human colostrum. To evaluate detection in two conditions of stimulus delivery, we first presented the odor of total colostrum against water. Second, the hedonic specificity of total colostrum odor was tested against vanilla odor. Third, we delivered only the fresh effluvium of colostrum separated from the colostrum matrix; the stability of this colostrum effluvium was then tested after deep congelation; finally, after sorptive extraction of fresh colostrum headspace, we assessed the activity of colostrum volatiles eluting from the gas chromatograph (GC). Regardless of the stimulus‐delivery method, neonates displayed attraction reactions (HR decrease) as well as appetitive oral responses to the odor of total colostrum but not to vanilla odor. The effluvium separated from the fresh colostrum matrix remained appetitive but appeared labile under deep freezing. Finally, volatiles from fresh colostrum effluvium remained behaviorally active after GC elution, although at lower magnitude. In sum, fresh colostrum effluvium and its eluate elicited a consistent increase in newborns’ oral activity (relative to water or vanilla), and they induced shallow HR decrease. Newborns’ appetitive oral behavior was the most reproducible response criterion to the effluvium of colostrum. In conclusion, a set of unidentified volatile compounds from human colostrum is robust enough after extraction from the original matrix and chromatographic processing to continue eliciting appetitive responses in neonates, thus opening new directions to isolate and assay specific volatile molecules of colostrum. 10.1002/dev.22474 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/dev.22474 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_dev_22474 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Testing detectability, attractivity, hedonic specificity, extractability, and robustness of colostrum odor—Toward an olfactory bioassay for human neonates Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal Developmental Psychobiology Testing detectability, attractivity, hedonic specificity, extractability, and robustness of colostrum odor—Toward an olfactory bioassay for human neonates Magali Klaey‐Tassone Robert Soussignan Karine Durand Sarah Le Roy Fabrice Damon Angélique Villière Catherine Fillonneau Carole Prost Bruno Patris Paul Sagot Benoist Schaal Developmental Psychobiology AbstractHuman milk odor is attractive and appetitive for human newborns. Here, we studied behavioral and heart‐rate (HR) responses of 2‐day‐old neonates to the odor of human colostrum. To evaluate detection in two conditions of stimulus delivery, we first presented the odor of total colostrum against water. Second, the hedonic specificity of total colostrum odor was tested against vanilla odor. Third, we delivered only the fresh effluvium of colostrum separated from the colostrum matrix; the stability of this colostrum effluvium was then tested after deep congelation; finally, after sorptive extraction of fresh colostrum headspace, we assessed the activity of colostrum volatiles eluting from the gas chromatograph (GC). Regardless of the stimulus‐delivery method, neonates displayed attraction reactions (HR decrease) as well as appetitive oral responses to the odor of total colostrum but not to vanilla odor. The effluvium separated from the fresh colostrum matrix remained appetitive but appeared labile under deep freezing. Finally, volatiles from fresh colostrum effluvium remained behaviorally active after GC elution, although at lower magnitude. In sum, fresh colostrum effluvium and its eluate elicited a consistent increase in newborns’ oral activity (relative to water or vanilla), and they induced shallow HR decrease. Newborns’ appetitive oral behavior was the most reproducible response criterion to the effluvium of colostrum. In conclusion, a set of unidentified volatile compounds from human colostrum is robust enough after extraction from the original matrix and chromatographic processing to continue eliciting appetitive responses in neonates, thus opening new directions to isolate and assay specific volatile molecules of colostrum. 10.1002/dev.22474 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Testing detectability, attractivity, hedonic specificity, extractability, and robustness of colostrum odor—Toward an olfactory bioassay for human neonates |
| topic | Developmental Psychobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/dev.22474 |