Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat
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2024
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| author | Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada |
| author_facet | Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada |
| collection | Wiley Open Access |
| contents | Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada Developmental Psychobiology AbstractMaternal deprivation, as a result of the artificial rearing (AR) paradigm, disturbs electrophysiological and histological characteristics of the peripheral sensory sural (SU) nerve of infant and adult male rats. Such changes are prevented by providing tactile or social stimulation during isolation. AR also affects the female rat's brain and behavior; however, it is unknown whether this early adverse experience also alters their SU nerve development or if tactile stimulation might prevent these possible developmental effects. To assess these possibilities, the electrophysiological and histological characteristics of the SU nerve from adult diestrus AR female rats that: (i) received no tactile stimulation (AR group), (ii) received tactile stimulation in the anogenital and body area (AR‐Tactile group), or (iii) were mother reared (MR group) were determined. We found that the amplitude, but not the area, of the evoked compound action potential response in SU nerves of AR rats was lower than those of SU nerves of MR female rats. Tactile stimulation prevented these effects.Additionally, we found a reduction in the outer diameter and myelin thickness of axons, as well as a large proportion of axons with low myelin thickness in nerves of AR rats compared to the nerves of the MR and AR‐Tactile groups of rats; however, tactile stimulation only partially prevented these effects. Our data indicate that maternal deprivation disturbs the development of sensory SU nerves in female rats, whereas tactile stimulation partially prevents the changes generated by AR. Considering that our previous studies have shown more severe effects of AR on male SU nerve development, we suggest that sex‐associated factors may be involved in these processes. 10.1002/dev.22486 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/dev.22486 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_dev_22486 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada Developmental Psychobiology Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat Angel I. Melo Rene Zempoalteca Gabriela Ramirez‐Funez Arely Anaya‐Hernández Mercedes G. Porras Elsa L. Aguirre‐Benítez Margarita González del Pliego Pérez‐Torres Armando Ismael Jiménez‐Estrada Developmental Psychobiology AbstractMaternal deprivation, as a result of the artificial rearing (AR) paradigm, disturbs electrophysiological and histological characteristics of the peripheral sensory sural (SU) nerve of infant and adult male rats. Such changes are prevented by providing tactile or social stimulation during isolation. AR also affects the female rat's brain and behavior; however, it is unknown whether this early adverse experience also alters their SU nerve development or if tactile stimulation might prevent these possible developmental effects. To assess these possibilities, the electrophysiological and histological characteristics of the SU nerve from adult diestrus AR female rats that: (i) received no tactile stimulation (AR group), (ii) received tactile stimulation in the anogenital and body area (AR‐Tactile group), or (iii) were mother reared (MR group) were determined. We found that the amplitude, but not the area, of the evoked compound action potential response in SU nerves of AR rats was lower than those of SU nerves of MR female rats. Tactile stimulation prevented these effects.Additionally, we found a reduction in the outer diameter and myelin thickness of axons, as well as a large proportion of axons with low myelin thickness in nerves of AR rats compared to the nerves of the MR and AR‐Tactile groups of rats; however, tactile stimulation only partially prevented these effects. Our data indicate that maternal deprivation disturbs the development of sensory SU nerves in female rats, whereas tactile stimulation partially prevents the changes generated by AR. Considering that our previous studies have shown more severe effects of AR on male SU nerve development, we suggest that sex‐associated factors may be involved in these processes. 10.1002/dev.22486 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat |
| topic | Developmental Psychobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/dev.22486 |