Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review

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Main Authors: Jennie E. Ryan, Mitchell Fruchtman, Andrea Sparr‐Jaswa, Amy Knehans, Brooke Worster
Format: Artículo Open Access
Published: Wiley 2024
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author Jennie E. Ryan
Mitchell Fruchtman
Andrea Sparr‐Jaswa
Amy Knehans
Brooke Worster
author_facet Jennie E. Ryan
Mitchell Fruchtman
Andrea Sparr‐Jaswa
Amy Knehans
Brooke Worster
Jennie E. Ryan
Mitchell Fruchtman
Andrea Sparr‐Jaswa
Amy Knehans
Brooke Worster
collection Wiley Open Access
contents Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review Jennie E. Ryan Mitchell Fruchtman Andrea Sparr‐Jaswa Amy Knehans Brooke Worster Developmental Psychobiology ABSTRACTThere is emerging evidence that the endocannabinoid system (ECS) plays a significant role in the pathophysiology of many psychiatric disorders, including attention deficit hyperactivity disorder (ADHD). Increasing evidence suggests that a number of neurobiological correlates between endogenous cannabinoid function and cognitive dysfunction are seen in ADHD, making the ECS a possible target for therapeutic interventions. Cannabis use and cannabis use disorder are more prevalent in individuals with ADHD, compared to the general population, and there is growing popular perception that cannabis is therapeutic for ADHD. However, the relationship between cannabis use and ADHD symptomology is poorly understood. Further understanding of the role of the ECS in ADHD pathophysiology and the molecular alterations that may be a target for treatment is needed. To further the science on this emerging area of research, this scoping review describes the preclinical and clinical evidence seeking to understand the relationship between the ECS and ADHD. 10.1002/dev.22540 http://creativecommons.org/licenses/by-nc-nd/4.0/
doi_str_mv 10.1002/dev.22540
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license_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
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spellingShingle Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review
Jennie E. Ryan
Mitchell Fruchtman
Andrea Sparr‐Jaswa
Amy Knehans
Brooke Worster
Developmental Psychobiology
Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review Jennie E. Ryan Mitchell Fruchtman Andrea Sparr‐Jaswa Amy Knehans Brooke Worster Developmental Psychobiology ABSTRACTThere is emerging evidence that the endocannabinoid system (ECS) plays a significant role in the pathophysiology of many psychiatric disorders, including attention deficit hyperactivity disorder (ADHD). Increasing evidence suggests that a number of neurobiological correlates between endogenous cannabinoid function and cognitive dysfunction are seen in ADHD, making the ECS a possible target for therapeutic interventions. Cannabis use and cannabis use disorder are more prevalent in individuals with ADHD, compared to the general population, and there is growing popular perception that cannabis is therapeutic for ADHD. However, the relationship between cannabis use and ADHD symptomology is poorly understood. Further understanding of the role of the ECS in ADHD pathophysiology and the molecular alterations that may be a target for treatment is needed. To further the science on this emerging area of research, this scoping review describes the preclinical and clinical evidence seeking to understand the relationship between the ECS and ADHD. 10.1002/dev.22540 http://creativecommons.org/licenses/by-nc-nd/4.0/
title Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review
topic Developmental Psychobiology
url https://onlinelibrary.wiley.com/doi/10.1002/dev.22540