Agomelatine Is Unable to Attenuate Kainic Acid–Induced Deficits in Early Life Communicative Behavior
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Wiley
2024
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| author | Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo |
| author_facet | Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo |
| collection | Wiley Open Access |
| contents | Agomelatine Is Unable to Attenuate Kainic Acid–Induced Deficits in Early Life Communicative Behavior Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo Developmental Psychobiology ABSTRACTEarly life seizures are associated with a variety of behavioral comorbidities. Among the most prevalent of these are deficits in communication. Auditory communicative behaviors in mice, known as ultrasonic vocalizations (USVs), can be used to assess potential treatments. Agomelatine is a melatonin agonist that effectively reduces behavioral comorbidities of seizures in adults; however, its ability to attenuate seizure‐induced communicative deficits in neonates is unknown. To address this, we administered C57 mice either saline or kainic acid (KA) on postnatal day (PD) 10. The mice then received either agomelatine or saline 1‐h post‐status epilepticus. On PD 11, we assessed the quantity of USVs produced, the duration, peak frequency, fundamental frequency, and amplitude of the vocalizations, as well as the call type utilization. We found that KA increased vocal production and reduced USV variability relative to controls. KA also increased USV duration and amplitude and significantly altered the types of calls produced. Agomelatine did not attenuate any of the deficits. Our study is the first to assess agomelatine's efficacy to correct USVs and thus provides an important point of context to the literature, indicating that despite its high therapeutic efficacy to attenuate other behavioral comorbidities of seizures, agomelatine's ability to correct neonatal communicative deficits is limited. 10.1002/dev.22543 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/dev.22543 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_dev_22543 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Agomelatine Is Unable to Attenuate Kainic Acid–Induced Deficits in Early Life Communicative Behavior Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo Developmental Psychobiology Agomelatine Is Unable to Attenuate Kainic Acid–Induced Deficits in Early Life Communicative Behavior Matthew S. Binder Zachary J. Pranske Samantha L. Hodges Paige D. Womble Eliesse M. Kwok Saul I. Quintero Andrew D. Kim David A. Narvaiz Joaquin N. Lugo Developmental Psychobiology ABSTRACTEarly life seizures are associated with a variety of behavioral comorbidities. Among the most prevalent of these are deficits in communication. Auditory communicative behaviors in mice, known as ultrasonic vocalizations (USVs), can be used to assess potential treatments. Agomelatine is a melatonin agonist that effectively reduces behavioral comorbidities of seizures in adults; however, its ability to attenuate seizure‐induced communicative deficits in neonates is unknown. To address this, we administered C57 mice either saline or kainic acid (KA) on postnatal day (PD) 10. The mice then received either agomelatine or saline 1‐h post‐status epilepticus. On PD 11, we assessed the quantity of USVs produced, the duration, peak frequency, fundamental frequency, and amplitude of the vocalizations, as well as the call type utilization. We found that KA increased vocal production and reduced USV variability relative to controls. KA also increased USV duration and amplitude and significantly altered the types of calls produced. Agomelatine did not attenuate any of the deficits. Our study is the first to assess agomelatine's efficacy to correct USVs and thus provides an important point of context to the literature, indicating that despite its high therapeutic efficacy to attenuate other behavioral comorbidities of seizures, agomelatine's ability to correct neonatal communicative deficits is limited. 10.1002/dev.22543 http://creativecommons.org/licenses/by/4.0/ |
| title | Agomelatine Is Unable to Attenuate Kainic Acid–Induced Deficits in Early Life Communicative Behavior |
| topic | Developmental Psychobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/dev.22543 |