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| Main Authors: | , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/dev.70033 |
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Table of Contents:
- Early Attachment Disruption Increases Central Sensitivity of Depressive‐Like Behavior to Stimulation by PGE‐2 Michael B. Hennessy Olivia Slomski Joel L. Spenny Tisha R. Sharma Patricia A. Schiml Terrence Deak Developmental Psychobiology ABSTRACTEarly disruption of filial attachment appears to sensitize underlying threat‐related processes to produce vulnerability for developing depression when encountering stressors later in life. Evidence indicates neuroinflammatory signaling mediates this effect, though exact mechanisms are poorly understood. In a guinea pig model, early periods of isolation from the mother produce depressive‐like behavior and fever, which sensitize with repeated isolation. Because cyclooxygenase inhibitors reduce these effects, the sensitization appears to involve prostaglandins such as PGE‐2. We asked if isolation increased central sensitivity to PGE‐2, which could underlie the sensitization process. Experiment 1 established that intraventricular (ICV) infusion of 1 or 3 µg of PGE‐2 increased depressive‐like behavior in pups. The 3 µg dose also produced an initial suppression and then a rise in core temperature. In Experiment 2, repeated isolation of pups sensitized depressive‐like behavior. Days later (early adolescence), 1 µg of ICV‐PGE‐2 increased depressive‐like behavior in previously isolated guinea pigs, but not in non‐previously isolated controls. Core temperature was unaffected. Thus, early isolation from the mother increased sensitivity of depressive‐like behavior, but not fever, to PGE‐2. Results suggest that increased sensitivity to PGE‐2 could play a role in the enhanced vulnerability to depression in adolescents previously exposed to early attachment disruption. 10.1002/dev.70033 http://onlinelibrary.wiley.com/termsAndConditions#vor