Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou |
| author_facet | Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou |
| collection | Wiley Open Access |
| contents | Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou Endocrinology, Diabetes & Metabolism ABSTRACTPurposeTo present a case series of Cushing's syndrome (CS) during pregnancy caused by adrenocortical adenomas, highlighting clinical features, hormonal assessments and outcomes.MethodsWe describe five pregnant women with CS, detailing clinical presentations and laboratory findings.ResultsCommon clinical features included a full moon face, buffalo back and severe hypertension. Elevated blood cortisol levels with circadian rhythm disruption and suppressed adrenocorticotrophic hormone (ACTH) levels were observed. Imaging revealed unilateral adrenal tumours. Two cases underwent laparoscopic adrenalectomies during the second trimester, while three had postpartum surgery. All required hormone replacement therapy, with postoperative pathological confirmation of adrenocortical adenomas.ConclusionDiagnosis of CS during pregnancy is challenging due to overlapping features with normal pregnancy: elevated blood cortisol levels and abnormal diurnal rhythm of blood cortisol, suppressed aid diagnosis. Treatment should be individualised due to a lack of explicit optimum therapeutic approaches. Laparoscopic adrenalectomy may be an optimal choice, along with multidisciplinary management including hormone replacement therapy. 10.1002/edm2.474 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/edm2.474 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_edm2_474 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou Endocrinology, Diabetes & Metabolism Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review Yan Wang Yufen An Xiaomei Hou Yanan Xu Zhen Li Xin Liu Fumin Zheng Mingze Sun Rendong Han Caixia Lu Jing Li Jun Zhou Endocrinology, Diabetes & Metabolism ABSTRACTPurposeTo present a case series of Cushing's syndrome (CS) during pregnancy caused by adrenocortical adenomas, highlighting clinical features, hormonal assessments and outcomes.MethodsWe describe five pregnant women with CS, detailing clinical presentations and laboratory findings.ResultsCommon clinical features included a full moon face, buffalo back and severe hypertension. Elevated blood cortisol levels with circadian rhythm disruption and suppressed adrenocorticotrophic hormone (ACTH) levels were observed. Imaging revealed unilateral adrenal tumours. Two cases underwent laparoscopic adrenalectomies during the second trimester, while three had postpartum surgery. All required hormone replacement therapy, with postoperative pathological confirmation of adrenocortical adenomas.ConclusionDiagnosis of CS during pregnancy is challenging due to overlapping features with normal pregnancy: elevated blood cortisol levels and abnormal diurnal rhythm of blood cortisol, suppressed aid diagnosis. Treatment should be individualised due to a lack of explicit optimum therapeutic approaches. Laparoscopic adrenalectomy may be an optimal choice, along with multidisciplinary management including hormone replacement therapy. 10.1002/edm2.474 http://creativecommons.org/licenses/by/4.0/ |
| title | Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review |
| topic | Endocrinology, Diabetes & Metabolism |
| url | https://onlinelibrary.wiley.com/doi/10.1002/edm2.474 |