Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy
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| Natura: | Artículo Open Access |
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Wiley
2025
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| author | Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi |
| author_facet | Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi |
| collection | Wiley Open Access |
| contents | Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi eFood ABSTRACT Oat ( Avena sativa ) is a health‐promoting food exhibiting prebiotic properties. We invented oat‐based postbiotics (Oat_PB) fermented with probiotics (mainly Lactobacillus and Bifidobacterium ) and comprehensively compared their chemical constitutions with the synbiotic form (Oat_SB). Oat_PB accumulated β ‐glucan, avenanthramides (2c, 2p, and 2f) as well as free amino acids, for example, threonine, valine, arginine, aspartate, citrulline, and taurine, while reducing total phenol, flavone, and protein. Oat_PB enriched metabolites affecting lipid and glucose metabolism. Probiotics‐derived oat foods mitigated high‐sucrose‐induced obesity, liver injury, and repaired lipid and glucose metabolism in rats, with Oat_PB showing most pronounced effects. Oat_PB reversed high‐sucrose disturbed hepatic fatty acid profiles, and regulated genes and proteins involved in lipid homeostasis. Oat_PB ameliorated gut dysbacteriosis by increasing Alloprevotella , Prevotella , and Akkermansia while inhibiting harmful bacteria. Collectively, our study demonstrates the additional value of probiotic‐derived oat foods beyond the raw oat materials in preventing metabolic homeostasis and gut dysbacteriosis. 10.1002/efd2.70052 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/efd2.70052 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_efd2_70052 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi eFood Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy Ruixue Wen Lanqi Zhou Wei Song Jiayao Lv Tianqi Liu Haizhou Wu Lin Shi eFood ABSTRACT Oat ( Avena sativa ) is a health‐promoting food exhibiting prebiotic properties. We invented oat‐based postbiotics (Oat_PB) fermented with probiotics (mainly Lactobacillus and Bifidobacterium ) and comprehensively compared their chemical constitutions with the synbiotic form (Oat_SB). Oat_PB accumulated β ‐glucan, avenanthramides (2c, 2p, and 2f) as well as free amino acids, for example, threonine, valine, arginine, aspartate, citrulline, and taurine, while reducing total phenol, flavone, and protein. Oat_PB enriched metabolites affecting lipid and glucose metabolism. Probiotics‐derived oat foods mitigated high‐sucrose‐induced obesity, liver injury, and repaired lipid and glucose metabolism in rats, with Oat_PB showing most pronounced effects. Oat_PB reversed high‐sucrose disturbed hepatic fatty acid profiles, and regulated genes and proteins involved in lipid homeostasis. Oat_PB ameliorated gut dysbacteriosis by increasing Alloprevotella , Prevotella , and Akkermansia while inhibiting harmful bacteria. Collectively, our study demonstrates the additional value of probiotic‐derived oat foods beyond the raw oat materials in preventing metabolic homeostasis and gut dysbacteriosis. 10.1002/efd2.70052 http://creativecommons.org/licenses/by/4.0/ |
| title | Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy |
| topic | eFood |
| url | https://iadns.onlinelibrary.wiley.com/doi/10.1002/efd2.70052 |