| _version_ | 1867011255979474945 |
|---|---|
| author | Ghazal Darfarin Janice Pluth |
| author_facet | Ghazal Darfarin Janice Pluth Ghazal Darfarin Janice Pluth |
| collection | Wiley Open Access |
| contents | Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance Ghazal Darfarin Janice Pluth Environmental and Molecular Mutagenesis ABSTRACTThe mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is mitochondrial DNA (mtDNA), which encodes key oxidative phosphorylation components. MtDNA integrity is preserved through quality control mechanisms, including fusion and fission dynamics, mitophagy, and nuclear‐encoded DNA repair. Disruption in these pathways contributes to mt dysfunction, oxidative stress, and genetic instability—hallmarks of aging and diseases. Additionally, redox signaling and NAD+ homeostasis integrate mt and nuclear responses, modulating transcriptional programs that support mt biogenesis and stress adaptation. This review explores the molecular mechanisms coordinating mito‐nuclear interactions, emphasizing their role in maintaining mtDNA integrity and cellular equilibrium. Understanding these processes provides insights into how mt dysfunction drives aging and disease, paving the way for targeted therapeutic strategies. 10.1002/em.70013 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/em.70013 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_em_70013 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance Ghazal Darfarin Janice Pluth Environmental and Molecular Mutagenesis Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance Ghazal Darfarin Janice Pluth Environmental and Molecular Mutagenesis ABSTRACTThe mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is mitochondrial DNA (mtDNA), which encodes key oxidative phosphorylation components. MtDNA integrity is preserved through quality control mechanisms, including fusion and fission dynamics, mitophagy, and nuclear‐encoded DNA repair. Disruption in these pathways contributes to mt dysfunction, oxidative stress, and genetic instability—hallmarks of aging and diseases. Additionally, redox signaling and NAD+ homeostasis integrate mt and nuclear responses, modulating transcriptional programs that support mt biogenesis and stress adaptation. This review explores the molecular mechanisms coordinating mito‐nuclear interactions, emphasizing their role in maintaining mtDNA integrity and cellular equilibrium. Understanding these processes provides insights into how mt dysfunction drives aging and disease, paving the way for targeted therapeutic strategies. 10.1002/em.70013 http://creativecommons.org/licenses/by/4.0/ |
| title | Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance |
| topic | Environmental and Molecular Mutagenesis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/em.70013 |