Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome
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| Natura: | Artículo Open Access |
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Wiley
2025
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| author | Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi |
| author_facet | Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi |
| collection | Wiley Open Access |
| contents | Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi Head & Neck ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023. Endpoints included overall survival (OS), local control (LC), progression‐free survival (PFS), toxicities, and QOL. Results Most tumors were located in the sinonasal cavity ( n = 32). Surgery was performed in 8 patients; 19 received immune checkpoint inhibitors post‐SSPT. The 3‐year OS, LC, and PFS were 50%, 83%, and 30%, respectively. Larger tumor volumes (≥ 20 cm 3 ) were linked to worse PFS. Grade 3 mucositis occurred in 13%. Late toxicities included sinus disorder, osteonecrosis, and blindness (3%–5%). QOL was largely preserved, with notable declines in pain, swallowing, and mouth opening. Conclusion SSPT provides favorable LC with acceptable toxicity. Effective systemic therapies are needed to improve long‐term outcomes. 10.1002/hed.70121 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1002/hed.70121 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_hed_70121 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi Head & Neck Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome Koichiro Nakajima Hiromitsu Iwata Gaku Takano Daiki Kojima Yukiko Hattori Yusuke Tsuzuki Shuou Sudo Kensuke Hayashi Toshiyuki Toshito Hideo Fukano Hiroyuki Ogino Akio Hiwatashi Head & Neck ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023. Endpoints included overall survival (OS), local control (LC), progression‐free survival (PFS), toxicities, and QOL. Results Most tumors were located in the sinonasal cavity ( n = 32). Surgery was performed in 8 patients; 19 received immune checkpoint inhibitors post‐SSPT. The 3‐year OS, LC, and PFS were 50%, 83%, and 30%, respectively. Larger tumor volumes (≥ 20 cm 3 ) were linked to worse PFS. Grade 3 mucositis occurred in 13%. Late toxicities included sinus disorder, osteonecrosis, and blindness (3%–5%). QOL was largely preserved, with notable declines in pain, swallowing, and mouth opening. Conclusion SSPT provides favorable LC with acceptable toxicity. Effective systemic therapies are needed to improve long‐term outcomes. 10.1002/hed.70121 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome |
| topic | Head & Neck |
| url | https://onlinelibrary.wiley.com/doi/10.1002/hed.70121 |