CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli |
| author_facet | Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli |
| collection | Wiley Open Access |
| contents | CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli Hematological Oncology ABSTRACT Chronic lymphocytic leukemia (CLL) is characterized by an extremely variable clinical course. Although several parameters have been shown to be associated with clinical outcomes in patients with CLL, there remains substantial intragroup clinical heterogeneity in otherwise molecularly and staging homogeneous CLL subgroups. We have recently shown that high catalase (CAT) expression identifies patients with an aggressive clinical course and that higher CAT expression is associated with the presence of the rs1001179 single nucleotide polymorphism (SNP) T allele in the CAT promoter. Herein, we genotyped CLL patients for CAT rs1001179 SNP in an exploratory study ( n = 235) and in a sequential independent validation study ( n = 531). Time‐to‐event modeling analyses for time‐to‐first‐treatment (TTFT) from the two patients' cohorts showed that TT genotype was associated with a shorter TTFT, independently of other currently used prognostic parameters in CLL. Moreover, the TT genotype identifies CLL patients with a faster clinical progression even within subgroups of patients with low‐risk biological and clinical hallmarks. In conclusion, our data show that the TT genotype identifies CLL patients with a shorter TTFT, pointing to this SNP as a possible prognostic factor, which can improve patients' risk stratification leading to better patient management and personalized therapeutic choices. 10.1002/hon.70002 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/hon.70002 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_hon_70002 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli Hematological Oncology CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia Marilisa Galasso Vittoria Salaorni Riccardo Moia Valentina Mozzo Ester Lovato Chiara Cosentino Omar Perbellini Simona Gambino Ornella Lovato Maria Elena Carazzolo Isacco Ferrarini Francesca M. Quaglia Massimo Donadelli Maria G. Romanelli Carlo Visco Mauro Krampera Gianluca Gaidano Maria T. Scupoli Hematological Oncology ABSTRACT Chronic lymphocytic leukemia (CLL) is characterized by an extremely variable clinical course. Although several parameters have been shown to be associated with clinical outcomes in patients with CLL, there remains substantial intragroup clinical heterogeneity in otherwise molecularly and staging homogeneous CLL subgroups. We have recently shown that high catalase (CAT) expression identifies patients with an aggressive clinical course and that higher CAT expression is associated with the presence of the rs1001179 single nucleotide polymorphism (SNP) T allele in the CAT promoter. Herein, we genotyped CLL patients for CAT rs1001179 SNP in an exploratory study ( n = 235) and in a sequential independent validation study ( n = 531). Time‐to‐event modeling analyses for time‐to‐first‐treatment (TTFT) from the two patients' cohorts showed that TT genotype was associated with a shorter TTFT, independently of other currently used prognostic parameters in CLL. Moreover, the TT genotype identifies CLL patients with a faster clinical progression even within subgroups of patients with low‐risk biological and clinical hallmarks. In conclusion, our data show that the TT genotype identifies CLL patients with a shorter TTFT, pointing to this SNP as a possible prognostic factor, which can improve patients' risk stratification leading to better patient management and personalized therapeutic choices. 10.1002/hon.70002 http://creativecommons.org/licenses/by/4.0/ |
| title | CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia |
| topic | Hematological Oncology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/hon.70002 |