Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study
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2026
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| author | Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa |
| author_facet | Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa |
| collection | Wiley Open Access |
| contents | Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa Health Science Reports ABSTRACT Background and Aims This study aimed to compare the clinical symptoms of mild COVID‐19 and influenza during a period when both diseases circulated in the 2023–2024 influenza season in Japan. Methods Outpatients diagnosed with COVID‐19, influenza A, or influenza B by antigen test kits at 10 medical facilities in Japan were enrolled. Data were collected from a self‐reported diary. Results Data from 347 COVID‐19, 392 influenza A, and 103 influenza B patients were analyzed. COVID‐19 patients were significantly older than those with influenza A and B ( p < 0.001). Sore throat was significantly more prevalent in COVID‐19 patients than in patients with influenza A or B (49.0% vs. 27.3% and 27.2%, p < 0.001). Cough and nasal discharge/congestion were significantly more common in influenza A and B patients than in COVID‐19 patients ( p < 0.001 and p < 0.001, respectively). Taste and smell dysfunction at Days 5 to 7 was more prevalent in COVID‐19 patients (6.9% and 6.9%, respectively) than in influenza A or B patients ( p < 0.001 and p < 0.001, respectively). Maximum body temperature was significantly lower in COVID‐19 patients than in influenza A or B patients (38.3°C vs. 38.9°C and 38.9°C, p < 0.001). The frequency of any symptoms over 14 days was significantly higher in COVID‐19 patients, particularly in those aged ≥ 40 years ( p < 0.001). Conclusion Mild COVID‐19 was associated with longer‐lasting symptoms than influenza, particularly in individuals aged ≥ 40 years. These results suggest a greater disease burden of COVID‐19, even in outpatients with mild disease, compared with influenza. 10.1002/hsr2.72039 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1002/hsr2.72039 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_hsr2_72039 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa Health Science Reports Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study Takuma Bando Hideyuki Ikematsu Naoki Kawai Tetsunari Maeda Woon Joo Lee Shinro Matsuura Osame Tanaka Takashi Kawashima Hareaki Yamamoto Ietaka Sato Ken‐ichi Doniwa Health Science Reports ABSTRACT Background and Aims This study aimed to compare the clinical symptoms of mild COVID‐19 and influenza during a period when both diseases circulated in the 2023–2024 influenza season in Japan. Methods Outpatients diagnosed with COVID‐19, influenza A, or influenza B by antigen test kits at 10 medical facilities in Japan were enrolled. Data were collected from a self‐reported diary. Results Data from 347 COVID‐19, 392 influenza A, and 103 influenza B patients were analyzed. COVID‐19 patients were significantly older than those with influenza A and B ( p < 0.001). Sore throat was significantly more prevalent in COVID‐19 patients than in patients with influenza A or B (49.0% vs. 27.3% and 27.2%, p < 0.001). Cough and nasal discharge/congestion were significantly more common in influenza A and B patients than in COVID‐19 patients ( p < 0.001 and p < 0.001, respectively). Taste and smell dysfunction at Days 5 to 7 was more prevalent in COVID‐19 patients (6.9% and 6.9%, respectively) than in influenza A or B patients ( p < 0.001 and p < 0.001, respectively). Maximum body temperature was significantly lower in COVID‐19 patients than in influenza A or B patients (38.3°C vs. 38.9°C and 38.9°C, p < 0.001). The frequency of any symptoms over 14 days was significantly higher in COVID‐19 patients, particularly in those aged ≥ 40 years ( p < 0.001). Conclusion Mild COVID‐19 was associated with longer‐lasting symptoms than influenza, particularly in individuals aged ≥ 40 years. These results suggest a greater disease burden of COVID‐19, even in outpatients with mild disease, compared with influenza. 10.1002/hsr2.72039 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study |
| topic | Health Science Reports |
| url | https://onlinelibrary.wiley.com/doi/10.1002/hsr2.72039 |