Antipsychotic‐Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia‐Related Obesity
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| Formato: | Artículo Open Access |
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Wiley
2024
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| author | Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur |
| author_facet | Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur |
| collection | Wiley Open Access |
| contents | Antipsychotic‐Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia‐Related Obesity Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur Human Psychopharmacology: Clinical and Experimental ABSTRACTObjectiveTo define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic‐treated schizophrenia patients.MethodsSeveral cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (n = 40) and non‐obese (n = 40) antipsychotic‐treated patients and compared with age‐and BMI‐matched controls (n = 80).ResultsSchizophrenia patients had higher leptin, TNF‐α, adiponectin, visfatin, resistin, P‐selectin, NPY, BDNF, CD40‐L, MCP‐1, and malondialdehyde, and lower IL‐6, ghrelin, neopterin, and vitamin E levels compared to their respective controls (p < 0.001). Total oxidant status was higher in non‐obese patients compared to controls (p < 0.001), total antioxidant capacity was higher in obese compared to non‐obese patients (p < 0.01), but vitamin A and paraoxonase levels were not different. High sensitive‐CRP levels were higher in obsese controls relative to non‐obese controls (p < 0.05) and in obese patients relative to non‐obese patients (p < 0.001). Fasting glucose, insulin, HbA1c, HOMA‐IR, uric acid, total cholesterol, and triglyceride concentrations were higher in obese patients compared to non‐obese patients. Insulin concentrations and HOMA‐IR were also higher in obese controls than in non‐obese controls.ConclusionsOur results suggest that inflammatory responses and oxidative stress develop independently from obesity in antipsychotic‐treated schizophrenia patients. However, schizophrenia‐induced obesity causes metabolic disturbances; thereby, obese schizophrenia patients are more liable to cardiovascular events and progress of metabolic syndrome than non‐obese patients. 10.1002/hup.2913 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/hup.2913 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_hup_2913 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Antipsychotic‐Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia‐Related Obesity Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur Human Psychopharmacology: Clinical and Experimental Antipsychotic‐Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia‐Related Obesity Emre Sarandol Asli Sarandol Sener Mercan Salih Saygin Eker Esma Surmen‐Gur Human Psychopharmacology: Clinical and Experimental ABSTRACTObjectiveTo define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic‐treated schizophrenia patients.MethodsSeveral cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (n = 40) and non‐obese (n = 40) antipsychotic‐treated patients and compared with age‐and BMI‐matched controls (n = 80).ResultsSchizophrenia patients had higher leptin, TNF‐α, adiponectin, visfatin, resistin, P‐selectin, NPY, BDNF, CD40‐L, MCP‐1, and malondialdehyde, and lower IL‐6, ghrelin, neopterin, and vitamin E levels compared to their respective controls (p < 0.001). Total oxidant status was higher in non‐obese patients compared to controls (p < 0.001), total antioxidant capacity was higher in obese compared to non‐obese patients (p < 0.01), but vitamin A and paraoxonase levels were not different. High sensitive‐CRP levels were higher in obsese controls relative to non‐obese controls (p < 0.05) and in obese patients relative to non‐obese patients (p < 0.001). Fasting glucose, insulin, HbA1c, HOMA‐IR, uric acid, total cholesterol, and triglyceride concentrations were higher in obese patients compared to non‐obese patients. Insulin concentrations and HOMA‐IR were also higher in obese controls than in non‐obese controls.ConclusionsOur results suggest that inflammatory responses and oxidative stress develop independently from obesity in antipsychotic‐treated schizophrenia patients. However, schizophrenia‐induced obesity causes metabolic disturbances; thereby, obese schizophrenia patients are more liable to cardiovascular events and progress of metabolic syndrome than non‐obese patients. 10.1002/hup.2913 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Antipsychotic‐Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia‐Related Obesity |
| topic | Human Psychopharmacology: Clinical and Experimental |
| url | https://onlinelibrary.wiley.com/doi/10.1002/hup.2913 |