Safety and efficacy of peripheral blood stem cells collection in healthy children and pediatric patients with thalassemia major weighing 20 kg or less
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Wiley
2024
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| _version_ | 1867002711966220288 |
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| author | Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu |
| author_facet | Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu |
| collection | Wiley Open Access |
| contents | Safety and efficacy of peripheral blood stem cells collection in healthy children and pediatric patients with thalassemia major weighing 20 kg or less Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu Journal of Clinical Apheresis AbstractBackgroundPeripheral blood stem cell (PBSC) collection in children poses challenges due to their small size, low body weight (BW), and unique pediatric physiology, especially among children weighing 20 kg (kg) or less.MethodsPBSC collection data of both healthy children and patients with thalassemia major (TM) weighing 20 kg or less between January 2013 and December 2020 were reviewed. Moreover, PBSCs characteristics along with various aspects of efficiency and safety between healthy donors and patients with TM were compared.ResultsA total of 262 PBSC procedures were performed on 255 children. Of these, 91 procedures were carried out on 85 allogeneic healthy donors, and 171 auto‐backup collections were performed on 170 patients with TM to ensure PBSC availability and prevent transplantation failure. A minimum pre‐apheresis hemoglobin (HGB) level of 60 g/L was discovered to be safe and feasible in patients with TM. The median CD34+ cell dose in the PBSC product during the initial apheresis procedure was higher in healthy donors compared to patients with TM (7.29 ± 5.28 × 106 cells/kg vs5.88 ± 4.23 × 106 cells/kg, P = .043). The total CD34+ cells/kg recipient weight exhibited a positive correlation with pre‐apheresis monocyte counts, but a negative correlation with donor weight. Apheresis significantly reduced hematocrit and platelet counts in the allogeneic group compared to the autologous group. Patients with TM experienced a higher occurrence of bone pain related to granulocyte colony‐stimulating factor treatment. Notably, no serious complications related to PBSCs mobilization, central venous catheter placement, or the apheresis procedure were observed in either group.ConclusionsPBSCs collection was both safe and effective in healthy children and pediatric patients with TM weighing 20 kg or less. 10.1002/jca.22102 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.22102 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_22102 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Safety and efficacy of peripheral blood stem cells collection in healthy children and pediatric patients with thalassemia major weighing 20 kg or less Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu Journal of Clinical Apheresis Safety and efficacy of peripheral blood stem cells collection in healthy children and pediatric patients with thalassemia major weighing 20 kg or less Libai Chen Jianyun Wen Xiaoxiao Xu Jing Du Yongsheng Ruan Xiaoqin Feng Juan Li Yuelin He Xuedong Wu Journal of Clinical Apheresis AbstractBackgroundPeripheral blood stem cell (PBSC) collection in children poses challenges due to their small size, low body weight (BW), and unique pediatric physiology, especially among children weighing 20 kg (kg) or less.MethodsPBSC collection data of both healthy children and patients with thalassemia major (TM) weighing 20 kg or less between January 2013 and December 2020 were reviewed. Moreover, PBSCs characteristics along with various aspects of efficiency and safety between healthy donors and patients with TM were compared.ResultsA total of 262 PBSC procedures were performed on 255 children. Of these, 91 procedures were carried out on 85 allogeneic healthy donors, and 171 auto‐backup collections were performed on 170 patients with TM to ensure PBSC availability and prevent transplantation failure. A minimum pre‐apheresis hemoglobin (HGB) level of 60 g/L was discovered to be safe and feasible in patients with TM. The median CD34+ cell dose in the PBSC product during the initial apheresis procedure was higher in healthy donors compared to patients with TM (7.29 ± 5.28 × 106 cells/kg vs5.88 ± 4.23 × 106 cells/kg, P = .043). The total CD34+ cells/kg recipient weight exhibited a positive correlation with pre‐apheresis monocyte counts, but a negative correlation with donor weight. Apheresis significantly reduced hematocrit and platelet counts in the allogeneic group compared to the autologous group. Patients with TM experienced a higher occurrence of bone pain related to granulocyte colony‐stimulating factor treatment. Notably, no serious complications related to PBSCs mobilization, central venous catheter placement, or the apheresis procedure were observed in either group.ConclusionsPBSCs collection was both safe and effective in healthy children and pediatric patients with TM weighing 20 kg or less. 10.1002/jca.22102 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Safety and efficacy of peripheral blood stem cells collection in healthy children and pediatric patients with thalassemia major weighing 20 kg or less |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.22102 |