Optimizing autologous stem cell collections for patients with multiple myeloma receiving G‐CSF and Plerixafor: A single center project
Fuente:
Wiley Open Access
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Artículo Open Access |
| Publicado: |
Wiley
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1867021432779702272 |
|---|---|
| author | Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson |
| author_facet | Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson |
| collection | Wiley Open Access |
| contents | Optimizing autologous stem cell collections for patients with multiple myeloma receiving G‐CSF and Plerixafor: A single center project Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson Journal of Clinical Apheresis AbstractBackgroundIncreasing indications for cellular therapy collections have stressed our healthcare system, with autologous collections having a longer than desired wait time until apheresis collection. This quality improvement initiative was undertaken to accommodate more patients within existing resources.Study Design and MethodsPatients with multiple myeloma who underwent autologous peripheral blood stem cell collection from October 2022 to April 2023 were included. Demographic, mobilization, laboratory, and apheresis data were retrospectively collected from the medical record.ResultsThis cohort included 120 patients (49.2% male), with a median age of 60 years. All received G‐CSF and 95% received pre‐emptive Plerixafor approximately 18 hours pre‐collection. Most (79%) had collection goals of at least 8 × 106/kg CD34 cells, with 63% over 70 years old having this high collection goal (despite 20 years of institutional data showing <1% over 70 years old have a second transplant). With collection efficiencies of 55.9%, 44% of patients achieved their collection goal in a single day apheresis collection. A platelet count <150 × 103/μL on the day of collection was a predictor for poor mobilization; among 27 patients with a low baseline platelet count, 17 did not achieve the collection goal and 2 failed to collect a transplantable dose.ConclusionsWith minor collection goal adjustments, 15% of all collection appointments could have been avoided over this 6‐month period. Other strategies to accommodate more patients include mobilization modifications (Plerixafor timing or substituting a longer acting drug), utilizing platelet counts to predict mobilization, and modifying apheresis collection volumes or schedule templates. 10.1002/jca.22127 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.22127 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_22127 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Optimizing autologous stem cell collections for patients with multiple myeloma receiving G‐CSF and Plerixafor: A single center project Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson Journal of Clinical Apheresis Optimizing autologous stem cell collections for patients with multiple myeloma receiving G‐CSF and Plerixafor: A single center project Ayda Javanbakht Stephanie Stringer Hollie Anderson Ellie Hamilton Anisha Philip Edmund K. Waller Amelia A. Langston Nisha Joseph John D. Roback Thomas Schneider H. Cliff Sullivan Jeanne E. Hendrickson Journal of Clinical Apheresis AbstractBackgroundIncreasing indications for cellular therapy collections have stressed our healthcare system, with autologous collections having a longer than desired wait time until apheresis collection. This quality improvement initiative was undertaken to accommodate more patients within existing resources.Study Design and MethodsPatients with multiple myeloma who underwent autologous peripheral blood stem cell collection from October 2022 to April 2023 were included. Demographic, mobilization, laboratory, and apheresis data were retrospectively collected from the medical record.ResultsThis cohort included 120 patients (49.2% male), with a median age of 60 years. All received G‐CSF and 95% received pre‐emptive Plerixafor approximately 18 hours pre‐collection. Most (79%) had collection goals of at least 8 × 106/kg CD34 cells, with 63% over 70 years old having this high collection goal (despite 20 years of institutional data showing <1% over 70 years old have a second transplant). With collection efficiencies of 55.9%, 44% of patients achieved their collection goal in a single day apheresis collection. A platelet count <150 × 103/μL on the day of collection was a predictor for poor mobilization; among 27 patients with a low baseline platelet count, 17 did not achieve the collection goal and 2 failed to collect a transplantable dose.ConclusionsWith minor collection goal adjustments, 15% of all collection appointments could have been avoided over this 6‐month period. Other strategies to accommodate more patients include mobilization modifications (Plerixafor timing or substituting a longer acting drug), utilizing platelet counts to predict mobilization, and modifying apheresis collection volumes or schedule templates. 10.1002/jca.22127 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Optimizing autologous stem cell collections for patients with multiple myeloma receiving G‐CSF and Plerixafor: A single center project |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.22127 |