Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study
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Wiley
2024
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| author | Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo |
| author_facet | Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo |
| collection | Wiley Open Access |
| contents | Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo Journal of Clinical Apheresis AbstractBackgroundPeripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatment.Materials and MethodsTwenty‐five HD patients affected by PAD stage IV Lerichè‐Fontaine and ischemic ulcer 1C or 2C according to the University of Texas Wound Classification System (UTWCS), without amelioration after traditional medical therapy and/or revascularization, were selected and underwent 12 Rheopheresis sessions in 10 weeks. Improvements in pain symptoms using Numerical Rating Scale (NRS), healing ulcers and laboratory hemorheological parameters have been evaluated.ResultsA clinically and statistically significant mean value reduction and of relative percentage differences between estimated marginal means (Δ), calculated at each visits, of NRS was observed, with a maximum value (−48.5%) between the first and last visit. At the end of the treatment period 14.3% of ulcers were completely healed, 46.4% downgraded, 53.6% were stable. Overall, no ulcers upgraded. A statistically significant reduction of the Δ, between the first and last visit, for fibrinogen (−16%) was also observed.ConclusionRheopheresis reduced overall painful symptoms; data suggest that it could heal or improve ulcers and hemorheological laboratory parameters in HD patients with PAD and ischemic ulcers resistant to standard therapies. 10.1002/jca.22132 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1002/jca.22132 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_22132 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo Journal of Clinical Apheresis Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study Claudia Altobelli Filippo Carone Fabiani Pietro Anastasio Corrado Pluvio Emanuela de Pascale Luigi Vernaglione Giuseppe Gernone Marina Di Luca Veronica Bertuzzi Paola Brescia Pierpaolo Toffoletto Mario D'Arezzo Maddalena Brustia Andreana De Mauri Doriana Chiarinotti Carmelo Loschiavo Matteo Grecò Filomena D'Elia Maria Anna Gallo Giovanni Tarroni Lorenzo Di Liberato Alessandra F Perna Giovambattista Capasso Giovanna Capolongo Journal of Clinical Apheresis AbstractBackgroundPeripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatment.Materials and MethodsTwenty‐five HD patients affected by PAD stage IV Lerichè‐Fontaine and ischemic ulcer 1C or 2C according to the University of Texas Wound Classification System (UTWCS), without amelioration after traditional medical therapy and/or revascularization, were selected and underwent 12 Rheopheresis sessions in 10 weeks. Improvements in pain symptoms using Numerical Rating Scale (NRS), healing ulcers and laboratory hemorheological parameters have been evaluated.ResultsA clinically and statistically significant mean value reduction and of relative percentage differences between estimated marginal means (Δ), calculated at each visits, of NRS was observed, with a maximum value (−48.5%) between the first and last visit. At the end of the treatment period 14.3% of ulcers were completely healed, 46.4% downgraded, 53.6% were stable. Overall, no ulcers upgraded. A statistically significant reduction of the Δ, between the first and last visit, for fibrinogen (−16%) was also observed.ConclusionRheopheresis reduced overall painful symptoms; data suggest that it could heal or improve ulcers and hemorheological laboratory parameters in HD patients with PAD and ischemic ulcers resistant to standard therapies. 10.1002/jca.22132 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.22132 |