Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome
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2024
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| author | Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo |
| author_facet | Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo |
| collection | Wiley Open Access |
| contents | Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo Journal of Clinical Apheresis ABSTRACTPlasma plays a crucial role in maintaining health through regulating coagulation and inflammation. Both are essential to respond to homeostatic threats such as traumatic injury or microbial infection; however, left unchecked, they can themselves cause damage. A well‐functioning plasma regulatory milieu controls the location, intensity, and duration of the response to injury or infection. In contrast, plasma failure can be conceptualized as a state in which these mechanisms are overwhelmed and unable to constrain coagulation and inflammation appropriately. This dysregulated state causes widespread tissue damage and multiple organ dysfunction syndrome. Unlike plasma derangements caused by individual factors, plasma failure is characterized by a heterogeneous set of plasma component deficiencies and excesses. Targeted therapies such as factor replacement or recombinant antibodies are thus inadequate to restore plasma function. Therapeutic plasma exchange offers the unique ability to remove harmful factors and replete exhausted components, thereby reestablishing appropriate regulation of coagulation and inflammation. 10.1002/jca.22147 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1002/jca.22147 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_22147 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo Journal of Clinical Apheresis Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome Matthew J. Foglia Jay S. Raval Jan C. Hofmann Joseph A. Carcillo Journal of Clinical Apheresis ABSTRACTPlasma plays a crucial role in maintaining health through regulating coagulation and inflammation. Both are essential to respond to homeostatic threats such as traumatic injury or microbial infection; however, left unchecked, they can themselves cause damage. A well‐functioning plasma regulatory milieu controls the location, intensity, and duration of the response to injury or infection. In contrast, plasma failure can be conceptualized as a state in which these mechanisms are overwhelmed and unable to constrain coagulation and inflammation appropriately. This dysregulated state causes widespread tissue damage and multiple organ dysfunction syndrome. Unlike plasma derangements caused by individual factors, plasma failure is characterized by a heterogeneous set of plasma component deficiencies and excesses. Targeted therapies such as factor replacement or recombinant antibodies are thus inadequate to restore plasma function. Therapeutic plasma exchange offers the unique ability to remove harmful factors and replete exhausted components, thereby reestablishing appropriate regulation of coagulation and inflammation. 10.1002/jca.22147 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.22147 |