Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti‐TNF‐Alpha Agents in the Patients With UC: A Case Report
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Wiley
2025
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| author | Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya |
| author_facet | Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya |
| collection | Wiley Open Access |
| contents | Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti‐TNF‐Alpha Agents in the Patients With UC: A Case Report Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya Journal of Clinical Apheresis ABSTRACTUlcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti‐tumor necrosis factor α (anti‐TNF‐α) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due to anti‐drug antibodies, poses a significant therapeutic challenge. This report describes a case where granulocyte and monocyte adsorptive apheresis (GMA) maintenance therapy successfully restored the efficacy of an anti‐TNF‐α agent in a 26‐year‐old male with active UC experiencing LOR to infliximab. Following GMA induction therapy and continued infliximab administration, clinical symptoms improved, fecal calprotectin levels decreased, and clinical remission was achieved. Long‐term maintenance with GMA enabled sustained clinical remission, with mucosal healing observed one year post‐therapy. This case suggests that GMA maintenance therapy may serve as a novel therapeutic approach for patients with active UC experiencing LOR to anti‐TNF‐α agents. However, further studies are warranted to elucidate the underlying mechanisms and validate its efficacy. 10.1002/jca.70030 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/jca.70030 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70030 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti‐TNF‐Alpha Agents in the Patients With UC: A Case Report Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya Journal of Clinical Apheresis Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti‐TNF‐Alpha Agents in the Patients With UC: A Case Report Nobuhiro Ueno Yu Kobayashi Aki Sakatani Tatsuya Dokoshi Keitaro Takahashi Katsuyoshi Ando Shin Kashima Kentaro Moriichi Hiroki Tanabe Yuki Kamikokura Mishie Tanino Mikihiro Fujiya Journal of Clinical Apheresis ABSTRACTUlcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti‐tumor necrosis factor α (anti‐TNF‐α) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due to anti‐drug antibodies, poses a significant therapeutic challenge. This report describes a case where granulocyte and monocyte adsorptive apheresis (GMA) maintenance therapy successfully restored the efficacy of an anti‐TNF‐α agent in a 26‐year‐old male with active UC experiencing LOR to infliximab. Following GMA induction therapy and continued infliximab administration, clinical symptoms improved, fecal calprotectin levels decreased, and clinical remission was achieved. Long‐term maintenance with GMA enabled sustained clinical remission, with mucosal healing observed one year post‐therapy. This case suggests that GMA maintenance therapy may serve as a novel therapeutic approach for patients with active UC experiencing LOR to anti‐TNF‐α agents. However, further studies are warranted to elucidate the underlying mechanisms and validate its efficacy. 10.1002/jca.70030 http://creativecommons.org/licenses/by/4.0/ |
| title | Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti‐TNF‐Alpha Agents in the Patients With UC: A Case Report |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70030 |