Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic GvHD
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2025
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867004600553308160 |
|---|---|
| author | Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi |
| author_facet | Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi |
| collection | Wiley Open Access |
| contents | Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic GvHD Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi Journal of Clinical Apheresis ABSTRACTWe report the case of a 50‐year‐old male with peripheral T‐cell lymphoma who underwent allogeneic hematopoietic stem cell transplantation and developed overlap chronic graft‐versus‐host disease (ocGvHD) requiring extracorporeal photopheresis (ECP). His clinical presentation included a maculopapular rash with jaundice, hepatosplenomegaly, hyperbilirubinemia, and elevated liver enzymes. Liver biopsy findings were not consistent with GvHD or lymphoma but were suggestive of drug‐induced hepatitis. ECP was initiated using the Therakos CellEx Photopheresis System. During the initial sessions, dark green plasma discoloration was observed, accompanied by multiple plasma/red blood cell interface‐related procedural alarms. These challenges were managed through various operator adjustments, and the procedures remained safe and effective. Over four ECP sessions, both the discoloration and opacity of the plasma progressively improved, in parallel with declining liver enzyme levels and a reduction in procedural alarms. This temporal association between hepatic recovery and improved interface stability during ECP has not been previously described in the context of ocGvHD. Although dark green plasma is an uncommon finding in this setting, it should prompt evaluation for underlying hepatic dysfunction and timely management of plasma/red blood cell interface issues to ensure safe and effective ECP delivery. 10.1002/jca.70045 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.70045 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70045 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic GvHD Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi Journal of Clinical Apheresis Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic GvHD Yandy Marx Castillo‐Aleman Aseel Suleiman Alsaid Shinnette Lumame Charisma Castelo Jay Mary Rose Roque Marlene Cato Yara Khaled Afifi Sheima Ali Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Nameer Al‐Saadawi Journal of Clinical Apheresis ABSTRACTWe report the case of a 50‐year‐old male with peripheral T‐cell lymphoma who underwent allogeneic hematopoietic stem cell transplantation and developed overlap chronic graft‐versus‐host disease (ocGvHD) requiring extracorporeal photopheresis (ECP). His clinical presentation included a maculopapular rash with jaundice, hepatosplenomegaly, hyperbilirubinemia, and elevated liver enzymes. Liver biopsy findings were not consistent with GvHD or lymphoma but were suggestive of drug‐induced hepatitis. ECP was initiated using the Therakos CellEx Photopheresis System. During the initial sessions, dark green plasma discoloration was observed, accompanied by multiple plasma/red blood cell interface‐related procedural alarms. These challenges were managed through various operator adjustments, and the procedures remained safe and effective. Over four ECP sessions, both the discoloration and opacity of the plasma progressively improved, in parallel with declining liver enzyme levels and a reduction in procedural alarms. This temporal association between hepatic recovery and improved interface stability during ECP has not been previously described in the context of ocGvHD. Although dark green plasma is an uncommon finding in this setting, it should prompt evaluation for underlying hepatic dysfunction and timely management of plasma/red blood cell interface issues to ensure safe and effective ECP delivery. 10.1002/jca.70045 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic GvHD |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70045 |