The Day Two Advantage: A Retrospective Paired Analysis of Consecutive HPC(A) Collections
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| Format: | Artículo Open Access |
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Wiley
2025
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| author | Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi |
| author_facet | Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi |
| collection | Wiley Open Access |
| contents | The Day Two Advantage: A Retrospective Paired Analysis of Consecutive HPC(A) Collections Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi Journal of Clinical Apheresis ABSTRACTThe hematopoietic progenitor cell apheresis [HPC(A)] is a cornerstone of stem cell transplantation. While multiple apheresis sessions are common in clinical practice, few studies have examined the procedural variability within the same donor across consecutive collections. This study aims to compare changes in the efficiency metrics between the first and second HPC(A) procedures. A retrospective analysis was conducted on paired HPC(A) procedures performed on the same donor between January 2023 and May 2025 at the Abu Dhabi Stem Cells Center. The predefined parameters, including the collection efficiencies (CE1, CE2, cruCE), performance ratio (PR), and total volume processed (TVP), were compared using the Wilcoxon signed‐rank tests. Effect sizes were calculated using Cohen's r, and associations between variables were assessed using the Spearman correlation. Of the 215 procedures screened, 90 met the inclusion criteria. Despite similar preapheresis CD34+ cell counts and flow rates, second‐day procedures demonstrated significantly improved CE1, CE2, and PR, with lower TVP. A large effect size was observed for the TVP/total blood volume (TBV) ratio (r = 0.63), and moderate‐to‐large effect sizes for CE2 (r = 0.41), PR (r = 0.47), and CE1 (r = 0.47). CE1 and CE2 correlated strongly with PR across both sessions, while CE2 correlated positively with TVP/TBV on day 1 (ρ = 0.47) and negatively on day 2 (ρ = −0.40). Second‐day HPC(A) sessions yielded superior efficiency despite reduced volume, supporting the value of individualized collection planning. These “day two advantages” may inform refinements in yield prediction and highlight the need for prospective studies to optimize apheresis strategies. 10.1002/jca.70046 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.70046 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70046 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The Day Two Advantage: A Retrospective Paired Analysis of Consecutive HPC(A) Collections Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi Journal of Clinical Apheresis The Day Two Advantage: A Retrospective Paired Analysis of Consecutive HPC(A) Collections Yandy Marx Castillo‐Aleman Carlos Agustin Villegas‐Valverde Antonio Alfonso Bencomo‐Hernandez Shinnette Lumame Charisma Castelo Jay Mary Rose‐Roque Marlene Cato Nameer Al‐Saadawi Mohamed Ibrahim Abu‐Haleeqa Inas El‐Najjar Yendry Ventura‐Carmenate Fatema Mohammed Al‐Kaabi Journal of Clinical Apheresis ABSTRACTThe hematopoietic progenitor cell apheresis [HPC(A)] is a cornerstone of stem cell transplantation. While multiple apheresis sessions are common in clinical practice, few studies have examined the procedural variability within the same donor across consecutive collections. This study aims to compare changes in the efficiency metrics between the first and second HPC(A) procedures. A retrospective analysis was conducted on paired HPC(A) procedures performed on the same donor between January 2023 and May 2025 at the Abu Dhabi Stem Cells Center. The predefined parameters, including the collection efficiencies (CE1, CE2, cruCE), performance ratio (PR), and total volume processed (TVP), were compared using the Wilcoxon signed‐rank tests. Effect sizes were calculated using Cohen's r, and associations between variables were assessed using the Spearman correlation. Of the 215 procedures screened, 90 met the inclusion criteria. Despite similar preapheresis CD34+ cell counts and flow rates, second‐day procedures demonstrated significantly improved CE1, CE2, and PR, with lower TVP. A large effect size was observed for the TVP/total blood volume (TBV) ratio (r = 0.63), and moderate‐to‐large effect sizes for CE2 (r = 0.41), PR (r = 0.47), and CE1 (r = 0.47). CE1 and CE2 correlated strongly with PR across both sessions, while CE2 correlated positively with TVP/TBV on day 1 (ρ = 0.47) and negatively on day 2 (ρ = −0.40). Second‐day HPC(A) sessions yielded superior efficiency despite reduced volume, supporting the value of individualized collection planning. These “day two advantages” may inform refinements in yield prediction and highlight the need for prospective studies to optimize apheresis strategies. 10.1002/jca.70046 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | The Day Two Advantage: A Retrospective Paired Analysis of Consecutive HPC(A) Collections |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70046 |