Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2026
|
| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/jca.70083 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Impact of Isovolemic Hemodilution‐Red Cell Exchange on Health‐Related Quality of Life in Patients With Sickle Cell Disease: A Pilot Study Alistair Murray Davinder Sidhu Natalia Rydz Dawn Goodyear Kelsey Uminski Journal of Clinical Apheresis ABSTRACT Sickle cell disease (SCD) negatively affects health‐related quality of life (HRQoL). Isovolemic hemodilution (IHD) red‐cell exchange (RCE) is being increasingly used to treat SCD‐related complications, but its impact on HRQoL has not been characterized. This single‐center pilot study assessed the effect of switching from chronic conventional RCE to IHD‐RCE on HRQoL. Adults with SCD receiving conventional RCE at the Foothills Medical Centre (Calgary, Canada) were assessed for eligibility to switch to IHD‐RCE in March–May 2023. The primary outcome was HRQoL assessed before and 6 months after switching using the Adult Sickle Cell Quality of Life Measurement Information System (ASCQ‐Me) questionnaire. Red blood cell (RBC) utilization, RCE characteristics, clinical parameters, and complications were also assessed before and after switching to IHD‐RCE. Five patients were included. Overall, HRQoL was stable 6 months after switching from conventional RCE to IHD‐RCE, with numeric improvements from baseline in sleep, stiffness, and emotional impact subscale scores. There were modest reductions in RBC utilization per RCE session but a small increase in RCE sessions per patient, with slightly fewer days between RCE sessions. Clinical parameters were largely unchanged 6 months after switching to IHD‐RCE except for decreased ferritin levels and iron saturation and increased total iron‐binding capacity. No emergency department visits or transfusion reactions were observed during follow‐up. This pilot study suggests that SCD‐related HRQoL is maintained after switching from conventional RCE to IHD‐RCE, with potential benefits on sleep, stiffness, and emotional impact. 10.1002/jca.70083 http://creativecommons.org/licenses/by-nc-nd/4.0/