Suppressive CD8 + T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis
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| Format: | Artículo Open Access |
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Wiley
2026
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| author | Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar |
| author_facet | Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar |
| collection | Wiley Open Access |
| contents | Suppressive CD8 + T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar Journal of Clinical Apheresis ABSTRACT Extracorporeal photopheresis (ECP) is a widely utilized immunomodulatory procedure with an incompletely defined mechanism. In graft‐versus‐host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T‐cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell–mediated antigen presentation and cytotoxic T cell activity. We investigated the role of CD8+ T cells in ECP using a murine model of multiple sclerosis (MS). ECP protected mice from disease, mitigated CNS pathology, and was dependent on CD8+ T cells. Translation to patients revealed increased numbers of suppressive CD8+ T‐cells. Functional assays identified enhanced suppressive capacity of CD8+ T‐cells in ECP patients and longitudinal studies found this occurred within 1 month of starting ECP. Using both a murine model and clinical samples, our findings reveal a mechanistic role for suppressive CD8+ T‐cells in mediating the effects of ECP, potentially providing a unifying mechanism for ECP's apparently dichotomous effects. 10.1002/jca.70094 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/jca.70094 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70094 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Suppressive CD8 + T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar Journal of Clinical Apheresis Suppressive CD8 + T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis Kai J. Rogers Kathryn L. Eschbacher Zeb Zacharias Kshitija Kale Michael P. Crawford Charles Michael Knudson Alexander W. Boyden Nitin J. Karandikar Journal of Clinical Apheresis ABSTRACT Extracorporeal photopheresis (ECP) is a widely utilized immunomodulatory procedure with an incompletely defined mechanism. In graft‐versus‐host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T‐cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell–mediated antigen presentation and cytotoxic T cell activity. We investigated the role of CD8+ T cells in ECP using a murine model of multiple sclerosis (MS). ECP protected mice from disease, mitigated CNS pathology, and was dependent on CD8+ T cells. Translation to patients revealed increased numbers of suppressive CD8+ T‐cells. Functional assays identified enhanced suppressive capacity of CD8+ T‐cells in ECP patients and longitudinal studies found this occurred within 1 month of starting ECP. Using both a murine model and clinical samples, our findings reveal a mechanistic role for suppressive CD8+ T‐cells in mediating the effects of ECP, potentially providing a unifying mechanism for ECP's apparently dichotomous effects. 10.1002/jca.70094 http://creativecommons.org/licenses/by/4.0/ |
| title | Suppressive CD8 + T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70094 |