Plasma Exchange in ANCA ‐Associated Vasculitis With Kidney Involvement: Differential Outcomes by Kidney Function in a Colombian Cohort
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| Formato: | Artículo Open Access |
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Wiley
2026
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| _version_ | 1867009777704370176 |
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| author | Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos |
| author_facet | Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos |
| collection | Wiley Open Access |
| contents | Plasma Exchange in ANCA ‐Associated Vasculitis With Kidney Involvement: Differential Outcomes by Kidney Function in a Colombian Cohort Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos Journal of Clinical Apheresis ABSTRACT ANCA‐associated vasculitis (AAV) frequently involves the kidneys and may progress to end‐stage kidney disease (ESKD). The benefit of plasma exchange (PLEX) in this setting remains uncertain. We conducted a retrospective cohort study of 163 patients with AAV and serum creatinine ≥ 1.5 mg/dL from two tertiary centers in Colombia, comparing PLEX versus no PLEX. The primary outcome was a composite of all‐cause mortality or ESKD. Overall, PLEX was not associated with a reduction in the composite outcome (adjusted hazard ratio [HR] 1.04, 95% CI 0.61–1.76). Among patients with baseline creatinine > 5.7 mg/dL, PLEX was associated with a lower risk of ESKD (adjusted HR 0.38, 95% CI 0.14–0.97) and a borderline reduction in the composite outcome (HR 0.45, p = 0.05), with no benefit in those with lower creatinine levels. PLEX was associated with increased in‐hospital infections (adjusted risk ratio 4.66, p = 0.001). These findings suggest a potential role for PLEX in selected patients with severe kidney dysfunction. 10.1002/jca.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.70099 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70099 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Plasma Exchange in ANCA ‐Associated Vasculitis With Kidney Involvement: Differential Outcomes by Kidney Function in a Colombian Cohort Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos Journal of Clinical Apheresis Plasma Exchange in ANCA ‐Associated Vasculitis With Kidney Involvement: Differential Outcomes by Kidney Function in a Colombian Cohort Clara Escorcia‐García Mauricio Restrepo‐Escobar Lina Aguirre José Nelson Carvajal Joaquín Rodelo‐Ceballos Journal of Clinical Apheresis ABSTRACT ANCA‐associated vasculitis (AAV) frequently involves the kidneys and may progress to end‐stage kidney disease (ESKD). The benefit of plasma exchange (PLEX) in this setting remains uncertain. We conducted a retrospective cohort study of 163 patients with AAV and serum creatinine ≥ 1.5 mg/dL from two tertiary centers in Colombia, comparing PLEX versus no PLEX. The primary outcome was a composite of all‐cause mortality or ESKD. Overall, PLEX was not associated with a reduction in the composite outcome (adjusted hazard ratio [HR] 1.04, 95% CI 0.61–1.76). Among patients with baseline creatinine > 5.7 mg/dL, PLEX was associated with a lower risk of ESKD (adjusted HR 0.38, 95% CI 0.14–0.97) and a borderline reduction in the composite outcome (HR 0.45, p = 0.05), with no benefit in those with lower creatinine levels. PLEX was associated with increased in‐hospital infections (adjusted risk ratio 4.66, p = 0.001). These findings suggest a potential role for PLEX in selected patients with severe kidney dysfunction. 10.1002/jca.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Plasma Exchange in ANCA ‐Associated Vasculitis With Kidney Involvement: Differential Outcomes by Kidney Function in a Colombian Cohort |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70099 |