Therapeutic Plasma Exchange Used in the Treatment of Clostridium perfringens Septicemia With Hemolysis
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2026
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867019798291939328 |
|---|---|
| author | Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski |
| author_facet | Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski |
| collection | Wiley Open Access |
| contents | Therapeutic Plasma Exchange Used in the Treatment of Clostridium perfringens Septicemia With Hemolysis Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski Journal of Clinical Apheresis ABSTRACT We report a case of fulminant Clostridium perfringens septicemia complicated by massive intravascular hemolysis in a 19‐year‐old male with acute myelogenous leukemia. The patient presented with severe anemia and laboratory evidence of profound hemolysis. Despite the high mortality associated with this condition, the patient was successfully treated with broad‐spectrum antibiotics, including clindamycin, and three consecutive sessions of therapeutic plasma exchange (TPE). TPE was employed to remove circulating α‐toxin and cell‐free hemoglobin, thereby mitigating ongoing hemolysis and organ injury. This case highlights the potential role of TPE, in conjunction with appropriate antimicrobial therapy, as an intervention in C. perfringens septicemia with hemolysis. 10.1002/jca.70110 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jca.70110 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jca_70110 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Therapeutic Plasma Exchange Used in the Treatment of Clostridium perfringens Septicemia With Hemolysis Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski Journal of Clinical Apheresis Therapeutic Plasma Exchange Used in the Treatment of Clostridium perfringens Septicemia With Hemolysis Theresa N. Kinard Lawrence Williams Mariah L. Schroeder Qun Lu Jill Adamski Journal of Clinical Apheresis ABSTRACT We report a case of fulminant Clostridium perfringens septicemia complicated by massive intravascular hemolysis in a 19‐year‐old male with acute myelogenous leukemia. The patient presented with severe anemia and laboratory evidence of profound hemolysis. Despite the high mortality associated with this condition, the patient was successfully treated with broad‐spectrum antibiotics, including clindamycin, and three consecutive sessions of therapeutic plasma exchange (TPE). TPE was employed to remove circulating α‐toxin and cell‐free hemoglobin, thereby mitigating ongoing hemolysis and organ injury. This case highlights the potential role of TPE, in conjunction with appropriate antimicrobial therapy, as an intervention in C. perfringens septicemia with hemolysis. 10.1002/jca.70110 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Therapeutic Plasma Exchange Used in the Treatment of Clostridium perfringens Septicemia With Hemolysis |
| topic | Journal of Clinical Apheresis |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jca.70110 |