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| Natura: | Artículo Open Access |
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Wiley
2024
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| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1002/jhet.4792 |
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| _version_ | 1867007553160871936 |
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| author | Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju |
| author_facet | Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju |
| collection | Wiley Open Access |
| contents | Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and molecular docking studies Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju Journal of Heterocyclic Chemistry Abstract A series of novel oxadiazole functionalized pyridopyrimidine derivatives prepared starting from 6‐methyl/ethyl‐2‐oxo‐4‐(trifluoromethyl)‐1,2‐dihydropyridine‐3‐carbonitrile 1 . This compound 1 on reaction with sulfuric acid obtained compound 2 , further compound 2 on reaction with chloroacetamide followed by reaction with ethoxy methylene malonic diethyl ester coupling and further cyclization to obtain compound 5 . Compound 5 on reaction with hydrazide hydrate obtained hydrazide derivatives 6 . Compound 6 on reaction with diverse substituted aromatic acids to get oxadiazole derivatives 7a–l . All the final compounds 7a–l evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL‐2); COLO 205—colon cancer (CCL‐222); HepG2—liver cancer (HB‐8065); and MCF7—breast cancer (HTB‐22) and promising compounds 7d and 7k have been identified and evaluated for molecular docking interactions. 10.1002/jhet.4792 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jhet.4792 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jhet_4792 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and molecular docking studies Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju Journal of Heterocyclic Chemistry Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and molecular docking studies Raghu Dasari Srinivas Gali Rajashekar Korra Namratha Vaddiraju Journal of Heterocyclic Chemistry Abstract A series of novel oxadiazole functionalized pyridopyrimidine derivatives prepared starting from 6‐methyl/ethyl‐2‐oxo‐4‐(trifluoromethyl)‐1,2‐dihydropyridine‐3‐carbonitrile 1 . This compound 1 on reaction with sulfuric acid obtained compound 2 , further compound 2 on reaction with chloroacetamide followed by reaction with ethoxy methylene malonic diethyl ester coupling and further cyclization to obtain compound 5 . Compound 5 on reaction with hydrazide hydrate obtained hydrazide derivatives 6 . Compound 6 on reaction with diverse substituted aromatic acids to get oxadiazole derivatives 7a–l . All the final compounds 7a–l evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL‐2); COLO 205—colon cancer (CCL‐222); HepG2—liver cancer (HB‐8065); and MCF7—breast cancer (HTB‐22) and promising compounds 7d and 7k have been identified and evaluated for molecular docking interactions. 10.1002/jhet.4792 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and molecular docking studies |
| topic | Journal of Heterocyclic Chemistry |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jhet.4792 |