Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID
Fuente:
Wiley Open Access
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Veröffentlicht: |
Wiley
2025
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1867005342397759488 |
|---|---|
| author | Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle |
| author_facet | Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle |
| collection | Wiley Open Access |
| contents | Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle JIMD Reports ABSTRACTSARS‐CoV‐2 infection and Long COVID (LC) might lead to a significant deterioration of physical and mental health. Wilson disease (WD) patients have a chronic liver and/or neuropsychiatric disease, making it particularly interesting to investigate LC in WD. 51 WD patients were retrospectively examined, evaluating physical and mental health by a survey and neuropsychological tests (SF‐12, PSQI, ISI, Epworth, Chalder‐fatigue scale, PHQ‐9, GAD‐7, PSS, FLei) before and ~11 months after SARS‐CoV‐2 infection. LC was defined as the development of new, at least moderately severe symptoms (shortness of breath, chest pain, fatigue, brain fog, exercise capacity, concentration disturbances) and/or worsening of pre‐existing symptoms. 70.6% had predominant hepatic and 29.4% had neuropsychiatric symptoms at WD diagnosis. Median age was 39 years; 56.1% were female. Patients were in stable maintenance phase with a median treatment duration of 23 years. When compared to before COVID‐19, WD patients had significantly worse physical life quality, sleeping quality, and fatigue. After COVID‐19, a high percentage of WD patients reported concentration disorders (60%), fatigue (55%), reduced exercise capacity (50%), shortness of breath (40%), chest pain (20%) and feeling of brain fog (15%). 39.2% (n = 20) of the WD patients were classified as LC. This LC‐WD subgroup showed significantly impaired quality of life, a high stress level, and sleeping disturbances, fatigue, depression, anxiety, and cognitive impairment. A large proportion of WD patients experience LC symptoms, reduced life quality, and sleeping disorders after SARS‐CoV‐2 infection. WD patients post‐infection should be well monitored and supported if they develop persisting symptoms or neuro‐psychological problems. 10.1002/jmd2.70021 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/jmd2.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jmd2_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle JIMD Reports Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID Isabelle Mohr Maximilian Brand Christophe Weber Andrea Langel Jessica Langel Patrick Michl Viola Yuriko Leidner Alexander Olkus Sebastian Köhrer Uta Merle JIMD Reports ABSTRACTSARS‐CoV‐2 infection and Long COVID (LC) might lead to a significant deterioration of physical and mental health. Wilson disease (WD) patients have a chronic liver and/or neuropsychiatric disease, making it particularly interesting to investigate LC in WD. 51 WD patients were retrospectively examined, evaluating physical and mental health by a survey and neuropsychological tests (SF‐12, PSQI, ISI, Epworth, Chalder‐fatigue scale, PHQ‐9, GAD‐7, PSS, FLei) before and ~11 months after SARS‐CoV‐2 infection. LC was defined as the development of new, at least moderately severe symptoms (shortness of breath, chest pain, fatigue, brain fog, exercise capacity, concentration disturbances) and/or worsening of pre‐existing symptoms. 70.6% had predominant hepatic and 29.4% had neuropsychiatric symptoms at WD diagnosis. Median age was 39 years; 56.1% were female. Patients were in stable maintenance phase with a median treatment duration of 23 years. When compared to before COVID‐19, WD patients had significantly worse physical life quality, sleeping quality, and fatigue. After COVID‐19, a high percentage of WD patients reported concentration disorders (60%), fatigue (55%), reduced exercise capacity (50%), shortness of breath (40%), chest pain (20%) and feeling of brain fog (15%). 39.2% (n = 20) of the WD patients were classified as LC. This LC‐WD subgroup showed significantly impaired quality of life, a high stress level, and sleeping disturbances, fatigue, depression, anxiety, and cognitive impairment. A large proportion of WD patients experience LC symptoms, reduced life quality, and sleeping disorders after SARS‐CoV‐2 infection. WD patients post‐infection should be well monitored and supported if they develop persisting symptoms or neuro‐psychological problems. 10.1002/jmd2.70021 http://creativecommons.org/licenses/by/4.0/ |
| title | Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID |
| topic | JIMD Reports |
| url | https://onlinelibrary.wiley.com/doi/10.1002/jmd2.70021 |