Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment
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| Format: | Artículo Open Access |
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2024
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| _version_ | 1867005061268242432 |
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| author | Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu |
| author_facet | Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu |
| collection | Wiley Open Access |
| contents | Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu Journal of the Science of Food and Agriculture AbstractBACKGROUNDRed Panax notoginseng (RPN) is one of the major processed products of P. notoginseng (PN), with more effective biological activities. However, the traditional processing method of RPN has some disadvantages, such as low conversion rate of ginsenosides and long processing time.RESULTSIn this work, we developed a green, safe, and efficient approach for RPN processing by aspartic acid impregnation pretreatment. Our results showed that the optimized temperature, steaming time, and concentration of aspartic acid were 120 °C, 1 h, and 3% respectively. The original ginsenosides in PN treated by aspartic acid (Asp‐PN) were completely converted to rare saponins at 120 °C within just 1 h. The concentration of the rare ginsenosides in Asp‐PN was two times higher than that in untreated RPN. In addition, we examined the protective effect of RPN and Asp‐PN on acetaminophen‐induced liver injury in a mouse model. The results showed that Asp‐PN has significantly more potent hepatoprotective action than the RPN. The hepatoprotection of Asp‐PN in acetaminophen‐induced hepatotoxicity may be due to its anti‐oxidative stress, anti‐apoptotic, and anti‐inflammatory activities.CONCLUSIONThese results indicated that aspartic acid impregnation pretreatment may provide an effective method to shorten the steaming time, improve the conversion rate of ginsenosides, and enhance hepatoprotective activity of RPN. © 2024 Society of Chemical Industry. 10.1002/jsfa.13440 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/jsfa.13440 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_jsfa_13440 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu Journal of the Science of Food and Agriculture Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment Ying Cui Jianfa Wu Danli Zhang Dan Li Jing Zhang Wei Li Chongzhi Wang Chunsu Yuan Zhi Liu Journal of the Science of Food and Agriculture AbstractBACKGROUNDRed Panax notoginseng (RPN) is one of the major processed products of P. notoginseng (PN), with more effective biological activities. However, the traditional processing method of RPN has some disadvantages, such as low conversion rate of ginsenosides and long processing time.RESULTSIn this work, we developed a green, safe, and efficient approach for RPN processing by aspartic acid impregnation pretreatment. Our results showed that the optimized temperature, steaming time, and concentration of aspartic acid were 120 °C, 1 h, and 3% respectively. The original ginsenosides in PN treated by aspartic acid (Asp‐PN) were completely converted to rare saponins at 120 °C within just 1 h. The concentration of the rare ginsenosides in Asp‐PN was two times higher than that in untreated RPN. In addition, we examined the protective effect of RPN and Asp‐PN on acetaminophen‐induced liver injury in a mouse model. The results showed that Asp‐PN has significantly more potent hepatoprotective action than the RPN. The hepatoprotection of Asp‐PN in acetaminophen‐induced hepatotoxicity may be due to its anti‐oxidative stress, anti‐apoptotic, and anti‐inflammatory activities.CONCLUSIONThese results indicated that aspartic acid impregnation pretreatment may provide an effective method to shorten the steaming time, improve the conversion rate of ginsenosides, and enhance hepatoprotective activity of RPN. © 2024 Society of Chemical Industry. 10.1002/jsfa.13440 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment |
| topic | Journal of the Science of Food and Agriculture |
| url | https://scijournals.onlinelibrary.wiley.com/doi/10.1002/jsfa.13440 |