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| Main Authors: | , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2024
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/mco2.607 |
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Table of Contents:
- Targeting CD300ld to normalize the tumor microenvironment: an emerging insight in cancer immunotherapy Lin‐Zhu Zhang Xu He Hai‐Dong Zhu MedComm AbstractIn a recent Nature elegant study, Wang et al. identified CD300ld, a novel functionally highly conserved tumor immunosuppressive receptor, highly expressed specifically on polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSCs), as well as a key receptor in the regulation of recruitment and immunosuppressive function of PMN‐MDSCs. Targeting CD300ld could remodel the tumor immune microenvironment, resulting in a broad‐spectrum anti‐tumor effect. 10.1002/mco2.607 http://creativecommons.org/licenses/by/4.0/