Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling
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| Natura: | Artículo Open Access |
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Wiley
2025
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| author | Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu |
| author_facet | Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu |
| collection | Wiley Open Access |
| contents | Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu MedComm ABSTRACT Histone lactylation, particularly histone H3 lysine 18 lactylation (H3K18la), modulates gene expression profile in diverse cellular processes, which has emerged as a critical factor in cardiovascular disease pathogenesis. However, its specific role in cardiac hypertrophy remains unclear. This study investigates the mechanism of H3K18la in promoting cardiac hypertrophy using transverse aortic constriction‐induced mice model and a phenylephrine‐induced hypertrophic cardiomyocyte model. We found that elevated levels of Pan‐Kla and H3K18la were detected in hypertrophic left ventricular tissues and cardiomyocytes, accompanied by increased heart and left ventricle weights, enlarged cardiomyocyte cross‐sectional areas and heightened expression of ANP, BNP, and β‐MHC. Clinical observations revealed a positive correlation between serum lactate levels and hypertrophic cardiomyopathy in patients. Furthermore, inhibition of lactylation reversed these effects, suggesting a direct role of H3K18la in hypertrophic gene expression. Mechanistically, H3K18la was found to interact with GATA4, enhancing its transcriptional activity as demonstrated by increased ANP promoter activity. Moreover, suppression of GATA4 mitigated the hypertrophic response, highlighting its crucial role downstream of H3K18la. Our findings identify H3K18la lactylation as a novel epigenetic mechanism driving cardiac hypertrophy through GATA4 activation. This implicates potential therapeutic targets for hypertrophic heart diseases. 10.1002/mco2.70421 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/mco2.70421 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mco2_70421 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu MedComm Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling Mingzhu Wang Zixian Liu Yongbo Ma Da Li Yuan Lin Yani Wang Deyu Fu Haidong Guo Liang Hu MedComm ABSTRACT Histone lactylation, particularly histone H3 lysine 18 lactylation (H3K18la), modulates gene expression profile in diverse cellular processes, which has emerged as a critical factor in cardiovascular disease pathogenesis. However, its specific role in cardiac hypertrophy remains unclear. This study investigates the mechanism of H3K18la in promoting cardiac hypertrophy using transverse aortic constriction‐induced mice model and a phenylephrine‐induced hypertrophic cardiomyocyte model. We found that elevated levels of Pan‐Kla and H3K18la were detected in hypertrophic left ventricular tissues and cardiomyocytes, accompanied by increased heart and left ventricle weights, enlarged cardiomyocyte cross‐sectional areas and heightened expression of ANP, BNP, and β‐MHC. Clinical observations revealed a positive correlation between serum lactate levels and hypertrophic cardiomyopathy in patients. Furthermore, inhibition of lactylation reversed these effects, suggesting a direct role of H3K18la in hypertrophic gene expression. Mechanistically, H3K18la was found to interact with GATA4, enhancing its transcriptional activity as demonstrated by increased ANP promoter activity. Moreover, suppression of GATA4 mitigated the hypertrophic response, highlighting its crucial role downstream of H3K18la. Our findings identify H3K18la lactylation as a novel epigenetic mechanism driving cardiac hypertrophy through GATA4 activation. This implicates potential therapeutic targets for hypertrophic heart diseases. 10.1002/mco2.70421 http://creativecommons.org/licenses/by/4.0/ |
| title | Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling |
| topic | MedComm |
| url | https://onlinelibrary.wiley.com/doi/10.1002/mco2.70421 |