Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM/DSS‐Induced Colon Cancer, in Part, by an Acetate‐Mediated Reduction in TH17 Cell Differentiation
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| Format: | Artículo Open Access |
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2025
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| _version_ | 1867002420070973440 |
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| author | Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal |
| author_facet | Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal |
| collection | Wiley Open Access |
| contents | Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM/DSS‐Induced Colon Cancer, in Part, by an Acetate‐Mediated Reduction in TH17 Cell Differentiation Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal Molecular Nutrition & Food Research ABSTRACTSince our previous studies found a low‐carbohydrate (CHO) diet containing soy protein and fish oil (i.e., 15%Amylose/Soy/FO) significantly reduced tobacco carcinogen‐induced lung nodules in A/J mice, breast tumors in C3(1)/Tag mice, and myelomalignancy in miR‐146a knockout mice, we asked herein if this CHO diet could also reduce colorectal cancer. We tested the efficacy of the 15%Amylose/Soy/FO diet in preventing colitis‐induced colorectal cancer using an azoxymethane/dextran sodium sulfate BALB/c mouse model. The 15%Amylose/Soy/FO diet significantly reduced colon tumor numbers compared to a Western diet and this was associated with a reduction in blood glucose, and a trend towards an increase in plasma β‐hydroxybutyrate and an increase in liver fatty acid synthase, suggesting a systemic metabolic shift from glucose to fatty acids as an energy source. In addition, our CHO diet reduced proinflammatory cytokines, induced a marked change in the fecal microbiome, an increase in cecal and fecal acetate, and a reduction in interleukin‐17A expressing cells in the colonic tumors of mice on the 15%Amylose/Soy/FO diet. Taken together, our results suggest the 15%Amylose/Soy/FO diet ameliorates colitis and prevents the subsequent development of colorectal cancer, in part by an acetate‐mediated reduction in TH17 cell development. 10.1002/mnfr.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/mnfr.70113 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mnfr_70113 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM/DSS‐Induced Colon Cancer, in Part, by an Acetate‐Mediated Reduction in TH17 Cell Differentiation Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal Molecular Nutrition & Food Research Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM/DSS‐Induced Colon Cancer, in Part, by an Acetate‐Mediated Reduction in TH17 Cell Differentiation Ingrid Elisia Michelle Yeung Sara Kowalski Amy Wong Colton Dietrich Vianne Chang Samantha Wu Serena Hollman Roger Dyer Khoi Nguyen Nguyen Gerald Krystal Molecular Nutrition & Food Research ABSTRACTSince our previous studies found a low‐carbohydrate (CHO) diet containing soy protein and fish oil (i.e., 15%Amylose/Soy/FO) significantly reduced tobacco carcinogen‐induced lung nodules in A/J mice, breast tumors in C3(1)/Tag mice, and myelomalignancy in miR‐146a knockout mice, we asked herein if this CHO diet could also reduce colorectal cancer. We tested the efficacy of the 15%Amylose/Soy/FO diet in preventing colitis‐induced colorectal cancer using an azoxymethane/dextran sodium sulfate BALB/c mouse model. The 15%Amylose/Soy/FO diet significantly reduced colon tumor numbers compared to a Western diet and this was associated with a reduction in blood glucose, and a trend towards an increase in plasma β‐hydroxybutyrate and an increase in liver fatty acid synthase, suggesting a systemic metabolic shift from glucose to fatty acids as an energy source. In addition, our CHO diet reduced proinflammatory cytokines, induced a marked change in the fecal microbiome, an increase in cecal and fecal acetate, and a reduction in interleukin‐17A expressing cells in the colonic tumors of mice on the 15%Amylose/Soy/FO diet. Taken together, our results suggest the 15%Amylose/Soy/FO diet ameliorates colitis and prevents the subsequent development of colorectal cancer, in part by an acetate‐mediated reduction in TH17 cell development. 10.1002/mnfr.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM/DSS‐Induced Colon Cancer, in Part, by an Acetate‐Mediated Reduction in TH17 Cell Differentiation |
| topic | Molecular Nutrition & Food Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.70113 |