Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study
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| Natura: | Artículo Open Access |
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Wiley
2024
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| author | Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh |
| author_facet | Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh |
| collection | Wiley Open Access |
| contents | Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh Medical Physics AbstractBackgroundHigh‐dose‐rate (HDR) brachytherapy (BT) has been acknowledged as a widely utilized treatment for patients with intermediate‐ and high‐risk prostate cancer, despite its side effects such as edema, incontinence, and impotence. Nevertheless, the treatment is consistently limited by the potential danger of excessive irradiation to organs‐at‐risk (OARs) like the urethra, bladder, and rectum.PurposeThis study aims to introduce curvilinear catheter implantation in the prostate gland for HDR treatment. The objective is to improve the radiation dose distribution by offering access channels conformal to the prostate anatomy. This approach seeks to minimize toxicity to nearby OARs while utilizing a reduced number of needles, potentially leading to improved clinical outcomes.MethodsCurvilinear catheters were first pre‐planned for an anonymized patient using Oncentra treatment planning system (TPS) and hybrid inverse planning optimization (HIPO) algorithm. The trajectories of the catheters were then analyzed using MATLAB to extract their radius of curvature. Tendon‐driven active needles were then used to implant curvilinear catheters inside an anthropomorphic phantom.ResultsProposed curvilinear catheter implantation resulted in significant improvement in terms of dosimetric constraints to the OARs and coverage to the prostate. Tendon‐driven active needles were shown to be capable of realizing the required pre‐planned curvatures inside prostate. It was shown that the active needle can realize a desired radius of curvature and a desired trajectory with an average accuracy of 9.1 ± 8.6 and 1.27 ± 0.50 mm in air and inside a tissue‐mimicking phantom, respectively.ConclusionThis work demonstrates the feasibility of using tendon‐driven active curvilinear catheter implantation in prostate to improve the outcomes of HDR‐BT via improved radiation dose distribution to the prostate and reduced toxicity to the OARs. 10.1002/mp.17113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/mp.17113 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mp_17113 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh Medical Physics Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study Blayton Padasdao Rex Imanaka Tarun K. Podder Bardia Konh Medical Physics AbstractBackgroundHigh‐dose‐rate (HDR) brachytherapy (BT) has been acknowledged as a widely utilized treatment for patients with intermediate‐ and high‐risk prostate cancer, despite its side effects such as edema, incontinence, and impotence. Nevertheless, the treatment is consistently limited by the potential danger of excessive irradiation to organs‐at‐risk (OARs) like the urethra, bladder, and rectum.PurposeThis study aims to introduce curvilinear catheter implantation in the prostate gland for HDR treatment. The objective is to improve the radiation dose distribution by offering access channels conformal to the prostate anatomy. This approach seeks to minimize toxicity to nearby OARs while utilizing a reduced number of needles, potentially leading to improved clinical outcomes.MethodsCurvilinear catheters were first pre‐planned for an anonymized patient using Oncentra treatment planning system (TPS) and hybrid inverse planning optimization (HIPO) algorithm. The trajectories of the catheters were then analyzed using MATLAB to extract their radius of curvature. Tendon‐driven active needles were then used to implant curvilinear catheters inside an anthropomorphic phantom.ResultsProposed curvilinear catheter implantation resulted in significant improvement in terms of dosimetric constraints to the OARs and coverage to the prostate. Tendon‐driven active needles were shown to be capable of realizing the required pre‐planned curvatures inside prostate. It was shown that the active needle can realize a desired radius of curvature and a desired trajectory with an average accuracy of 9.1 ± 8.6 and 1.27 ± 0.50 mm in air and inside a tissue‐mimicking phantom, respectively.ConclusionThis work demonstrates the feasibility of using tendon‐driven active curvilinear catheter implantation in prostate to improve the outcomes of HDR‐BT via improved radiation dose distribution to the prostate and reduced toxicity to the OARs. 10.1002/mp.17113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Curvilinear catheter implantation in HDR prostate brachytherapy: feasibility study |
| topic | Medical Physics |
| url | https://aapm.onlinelibrary.wiley.com/doi/10.1002/mp.17113 |