Performance evaluation of a small‐animal PET scanner with 213 mm axis using NEMA NU 4‐2008
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2024
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| author | Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei |
| author_facet | Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei |
| collection | Wiley Open Access |
| contents | Performance evaluation of a small‐animal PET scanner with 213 mm axis using NEMA NU 4‐2008 Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei Medical Physics AbstractBackgroundLong‐axis positron emission tomography (PET) has emerged as one of the recent research directions in PET due to its ability to significantly enhance sensitivity and counting performance for low‐dose imaging, rapid imaging, and whole‐body dynamic imaging.PurposeThe PET system presented in this study is a long‐axis animal PET based on lutetium–yttrium orthosilicate and silicon photomultiplier, designed for whole‐body imaging in rats. It features a diameter of 143 mm and an axial length of 213.3 mm. This study evaluated the performance of this PET system in accordance with the National Electrical Manufacturers Association (NEMA) NU 4‐2008 standards.MethodsThe performance evaluation was conducted according to the NEMA NU 4‐2008 standards in terms of spatial resolution, sensitivity, counting rate performance, scatter fraction (SF) and image quality. In addition, a rat imaging study was conducted to assess the imaging capability of this PET system.ResultsThe average energy resolution of the PET system was 12.87%, the average coincidence timing resolution was 751 ps. The FWHM of spatial resolution reconstructed by filtered back projection and 3D‐OSEM‐PSF algorithm at 5 mm radial offset from the axial center were 1.65 and 0.88 mm. The peak absolute sensitivity measured by a point source at the center of the field of view was evaluated as 6.71% (361–661 keV) and 10.31% (250–750 keV). For the mouse‐like phantom, the SF was 11.0% and the peak noise equivalent counting rate (NECR) was 1193 kcps at 94.2 MBq (2.54 mCi). For the rat‐like phantom, the SF was 26.8% and the NECR was 682.5 kcps at 78.6 MBq (2.12 mCi).ConclusionsThe performance measurement results demonstrate that this PET system exhibits high sensitivity and count rate performance, making it potential for high‐quality whole‐body dynamic imaging of rats. 10.1002/mp.17469 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/mp.17469 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mp_17469 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Performance evaluation of a small‐animal PET scanner with 213 mm axis using NEMA NU 4‐2008 Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei Medical Physics Performance evaluation of a small‐animal PET scanner with 213 mm axis using NEMA NU 4‐2008 Qing Wei Yingjie Wang Xianchao Huang Daowu Li Yushuang Zheng Peilin Wang Xiaoli Sun Pei Chai Xiaorou Han Shuangquan Liu Baotong Feng Wei Zhou Xiangtao Zeng Meiling Zhu Zhiming Zhang Long Wei Medical Physics AbstractBackgroundLong‐axis positron emission tomography (PET) has emerged as one of the recent research directions in PET due to its ability to significantly enhance sensitivity and counting performance for low‐dose imaging, rapid imaging, and whole‐body dynamic imaging.PurposeThe PET system presented in this study is a long‐axis animal PET based on lutetium–yttrium orthosilicate and silicon photomultiplier, designed for whole‐body imaging in rats. It features a diameter of 143 mm and an axial length of 213.3 mm. This study evaluated the performance of this PET system in accordance with the National Electrical Manufacturers Association (NEMA) NU 4‐2008 standards.MethodsThe performance evaluation was conducted according to the NEMA NU 4‐2008 standards in terms of spatial resolution, sensitivity, counting rate performance, scatter fraction (SF) and image quality. In addition, a rat imaging study was conducted to assess the imaging capability of this PET system.ResultsThe average energy resolution of the PET system was 12.87%, the average coincidence timing resolution was 751 ps. The FWHM of spatial resolution reconstructed by filtered back projection and 3D‐OSEM‐PSF algorithm at 5 mm radial offset from the axial center were 1.65 and 0.88 mm. The peak absolute sensitivity measured by a point source at the center of the field of view was evaluated as 6.71% (361–661 keV) and 10.31% (250–750 keV). For the mouse‐like phantom, the SF was 11.0% and the peak noise equivalent counting rate (NECR) was 1193 kcps at 94.2 MBq (2.54 mCi). For the rat‐like phantom, the SF was 26.8% and the NECR was 682.5 kcps at 78.6 MBq (2.12 mCi).ConclusionsThe performance measurement results demonstrate that this PET system exhibits high sensitivity and count rate performance, making it potential for high‐quality whole‐body dynamic imaging of rats. 10.1002/mp.17469 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Performance evaluation of a small‐animal PET scanner with 213 mm axis using NEMA NU 4‐2008 |
| topic | Medical Physics |
| url | https://aapm.onlinelibrary.wiley.com/doi/10.1002/mp.17469 |