| _version_ | 1867013214205640704 |
|---|---|
| author | Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen |
| author_facet | Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen |
| collection | Wiley Open Access |
| contents | Quantitative macromolecular proton fraction imaging using pulsed spin‐lock Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen Magnetic Resonance in Medicine AbstractPurposeRecent studies have shown that spin‐lock MRI can simplify quantitative magnetization transfer (MT) by eliminating its dependency on water pool parameters, removing the need for a T1 map in macromolecular proton fraction (MPF) quantification. However, its application is often limited by the requirement for long radiofrequency (RF) pulse durations, which are constrained by RF hardware capabilities despite remaining within specific absorption rate (SAR) safety limits.MethodsTo address this challenge, we propose a novel method, MPF mapping using pulsed spin‐lock (MPF‐PSL). MPF‐PSL employs a pulsed spin‐lock train with intermittent free precession periods, enabling extended total spin‐lock durations without exceeding hardware and specific absorption rate limits. A comprehensive analytical framework was developed to model the magnetization dynamics of the two‐pool MT system under pulsed spin‐lock, demonstrating that MPF‐PSL achieves MT‐specific quantification while minimizing confounding effects from the water pool. The proposed method is validated with Bloch–McConnell simulations, phantoms, and in vivo studies at 3T.ResultsBoth Bloch–McConnell simulations and phantom validation demonstrated that MPF‐PSL exhibits insensitivity to water pool parameters while enabling robust MPF quantification. In vivo validation studies confirmed the method's clinical utility in detecting collagen deposition in patients with liver fibrosis.ConclusionMPF‐PSL presents a practical solution for quantitative MT imaging, with strong potential for clinical applications. 10.1002/mrm.70021 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/mrm.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mrm_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Quantitative macromolecular proton fraction imaging using pulsed spin‐lock Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen Magnetic Resonance in Medicine Quantitative macromolecular proton fraction imaging using pulsed spin‐lock Qianxue Shan Ziqiang Yu Baiyan Jiang Jian Hou Qiuyi Shen Winnie Chiu Wing Chu Vincent Wai Sun Wong Weitian Chen Magnetic Resonance in Medicine AbstractPurposeRecent studies have shown that spin‐lock MRI can simplify quantitative magnetization transfer (MT) by eliminating its dependency on water pool parameters, removing the need for a T1 map in macromolecular proton fraction (MPF) quantification. However, its application is often limited by the requirement for long radiofrequency (RF) pulse durations, which are constrained by RF hardware capabilities despite remaining within specific absorption rate (SAR) safety limits.MethodsTo address this challenge, we propose a novel method, MPF mapping using pulsed spin‐lock (MPF‐PSL). MPF‐PSL employs a pulsed spin‐lock train with intermittent free precession periods, enabling extended total spin‐lock durations without exceeding hardware and specific absorption rate limits. A comprehensive analytical framework was developed to model the magnetization dynamics of the two‐pool MT system under pulsed spin‐lock, demonstrating that MPF‐PSL achieves MT‐specific quantification while minimizing confounding effects from the water pool. The proposed method is validated with Bloch–McConnell simulations, phantoms, and in vivo studies at 3T.ResultsBoth Bloch–McConnell simulations and phantom validation demonstrated that MPF‐PSL exhibits insensitivity to water pool parameters while enabling robust MPF quantification. In vivo validation studies confirmed the method's clinical utility in detecting collagen deposition in patients with liver fibrosis.ConclusionMPF‐PSL presents a practical solution for quantitative MT imaging, with strong potential for clinical applications. 10.1002/mrm.70021 http://creativecommons.org/licenses/by/4.0/ |
| title | Quantitative macromolecular proton fraction imaging using pulsed spin‐lock |
| topic | Magnetic Resonance in Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1002/mrm.70021 |