Enhanced 2D Spiral Cine DENSE MRI Using Low‐Rank Denoising for Improved Apparent Signal‐to‐Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility
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| Format: | Artículo Open Access |
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2026
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| author | Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong |
| author_facet | Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong |
| collection | Wiley Open Access |
| contents | Enhanced 2D Spiral Cine DENSE MRI Using Low‐Rank Denoising for Improved Apparent Signal‐to‐Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong Magnetic Resonance in Medicine ABSTRACT Purpose To develop a denoising technique for displacement encoding with stimulated echoes (DENSE) MRI that improves spatial resolution, efficiency, and accuracy, and enhances accessibility by implementing DENSE MRI at 0.55 T. Methods We developed a low‐rank denoising technique, which leverages multidimensional spiral cine DENSE MRI data for empirical noise estimation via Monte Carlo simulation combined with automatic noise suppression. Thirty‐six subjects (16 healthy, 20 with heart disease) were scanned at 3 T with breath‐hold standard‐resolution 2D cine DENSE (2.8 × 2.8 mm 2 ) in a short‐axis slice of the heart. In 10 healthy subjects, high‐resolution DENSE with 1.2 × 1.2 mm 2 was acquired. Apparent signal‐to‐noise ratio (SNR), phase SNR, scan efficiency (SNR per heartbeat per unit voxel size), and standard deviation of segmental circumferential myocardial strain (E cc ) were compared with Wilcoxon signed‐rank tests ( p < 0.05 considered significant). High‐resolution and standard‐resolution DENSE results were compared using Bland–Altman analysis. Lastly, we scanned seven healthy subjects at 0.55 T and 3 T, and compared E cc results. Results Apparent magnitude SNR, phase SNR and scan efficiency were significantly improved after denoising in both standard‐resolution and high‐resolution DENSE (all p < 0.01). Bland–Altman analysis showed denoised high‐resolution DENSE E cc had smaller mean differences (non‐denoised: 0.028 vs. denoised: 0.009) and narrower limits of agreement (non‐denoised: [−0.072, 0.127] vs. denoised: [−0.048, 0.065]), indicating improved accuracy. Strain measurements from denoised DENSE at 0.55 T showed good agreement with those from 3 T, demonstrating feasibility of DENSE MRI at 0.55 T. Conclusion Our proposed denoising technique may allow DENSE MRI with improved spatial resolution, efficiency, and accuracy, and enhanced accessibility at 0.55 T. 10.1002/mrm.70331 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/mrm.70331 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mrm_70331 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Enhanced 2D Spiral Cine DENSE MRI Using Low‐Rank Denoising for Improved Apparent Signal‐to‐Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong Magnetic Resonance in Medicine Enhanced 2D Spiral Cine DENSE MRI Using Low‐Rank Denoising for Improved Apparent Signal‐to‐Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility Shu‐Fu Shih Yuxiao Wu Siyue Li Zhengyang Ming Arutyun Pogosyan Fei Han Holden H. Wu J. Paul Finn Kim‐Lien Nguyen Xiaodong Zhong Magnetic Resonance in Medicine ABSTRACT Purpose To develop a denoising technique for displacement encoding with stimulated echoes (DENSE) MRI that improves spatial resolution, efficiency, and accuracy, and enhances accessibility by implementing DENSE MRI at 0.55 T. Methods We developed a low‐rank denoising technique, which leverages multidimensional spiral cine DENSE MRI data for empirical noise estimation via Monte Carlo simulation combined with automatic noise suppression. Thirty‐six subjects (16 healthy, 20 with heart disease) were scanned at 3 T with breath‐hold standard‐resolution 2D cine DENSE (2.8 × 2.8 mm 2 ) in a short‐axis slice of the heart. In 10 healthy subjects, high‐resolution DENSE with 1.2 × 1.2 mm 2 was acquired. Apparent signal‐to‐noise ratio (SNR), phase SNR, scan efficiency (SNR per heartbeat per unit voxel size), and standard deviation of segmental circumferential myocardial strain (E cc ) were compared with Wilcoxon signed‐rank tests ( p < 0.05 considered significant). High‐resolution and standard‐resolution DENSE results were compared using Bland–Altman analysis. Lastly, we scanned seven healthy subjects at 0.55 T and 3 T, and compared E cc results. Results Apparent magnitude SNR, phase SNR and scan efficiency were significantly improved after denoising in both standard‐resolution and high‐resolution DENSE (all p < 0.01). Bland–Altman analysis showed denoised high‐resolution DENSE E cc had smaller mean differences (non‐denoised: 0.028 vs. denoised: 0.009) and narrower limits of agreement (non‐denoised: [−0.072, 0.127] vs. denoised: [−0.048, 0.065]), indicating improved accuracy. Strain measurements from denoised DENSE at 0.55 T showed good agreement with those from 3 T, demonstrating feasibility of DENSE MRI at 0.55 T. Conclusion Our proposed denoising technique may allow DENSE MRI with improved spatial resolution, efficiency, and accuracy, and enhanced accessibility at 0.55 T. 10.1002/mrm.70331 http://creativecommons.org/licenses/by/4.0/ |
| title | Enhanced 2D Spiral Cine DENSE MRI Using Low‐Rank Denoising for Improved Apparent Signal‐to‐Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility |
| topic | Magnetic Resonance in Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1002/mrm.70331 |