Salvato in:
| Autori principali: | , , , , , , |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2026
|
| Soggetti: | |
| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1002/mrm.70430 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1867006862888534016 |
|---|---|
| author | Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska |
| author_facet | Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska |
| collection | Wiley Open Access |
| contents | Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska Magnetic Resonance in Medicine ABSTRACT Purpose Cystathionine (Cth) has emerged as a promising biomarker for identifying 1p/19q codeleted gliomas. However, little is known about the T 2 relaxation time constant of Cth in gliomas. The aim of this study was to measure the T 2 of Cth in vivo in glioma and compare it to the T 2 s of other metabolites at 3 T. Methods Ten participants with glioma were scanned at 3 T. Single‐voxel proton PRESS spectra were acquired at four echo‐times to determine the T 2 relaxation time constants of Cth, N ‐acetylaspartate, scyllo ‐inositol, total creatine, and total choline. Processed spectra were analyzed using LCModel, and the results were fitted using a mono‐exponential function to estimate the T 2 relaxation time constants. T 2 of Cth was also measured using high‐resolution NMR. Results The T 2 of Cth varied across participants (42–128 ms, with a mean and standard deviation of 75 ± 24 ms). Additionally, T 2 relaxation time constants of Cth were shorter than those of singlets measured in glioma in the same participants. Distinct differences in T 2 between the CH and CH 2 proton groups in Cth were also observed both in vitro and in vivo. Conclusion Knowledge of the T 2 of Cth should improve its quantification and may help increase understanding of the intracellular environment in glioma cells, potentially providing insights into tumor metabolism in future studies. 10.1002/mrm.70430 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/mrm.70430 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_mrm_70430 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska Magnetic Resonance in Medicine Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska Magnetic Resonance in Medicine ABSTRACT Purpose Cystathionine (Cth) has emerged as a promising biomarker for identifying 1p/19q codeleted gliomas. However, little is known about the T 2 relaxation time constant of Cth in gliomas. The aim of this study was to measure the T 2 of Cth in vivo in glioma and compare it to the T 2 s of other metabolites at 3 T. Methods Ten participants with glioma were scanned at 3 T. Single‐voxel proton PRESS spectra were acquired at four echo‐times to determine the T 2 relaxation time constants of Cth, N ‐acetylaspartate, scyllo ‐inositol, total creatine, and total choline. Processed spectra were analyzed using LCModel, and the results were fitted using a mono‐exponential function to estimate the T 2 relaxation time constants. T 2 of Cth was also measured using high‐resolution NMR. Results The T 2 of Cth varied across participants (42–128 ms, with a mean and standard deviation of 75 ± 24 ms). Additionally, T 2 relaxation time constants of Cth were shorter than those of singlets measured in glioma in the same participants. Distinct differences in T 2 between the CH and CH 2 proton groups in Cth were also observed both in vitro and in vivo. Conclusion Knowledge of the T 2 of Cth should improve its quantification and may help increase understanding of the intracellular environment in glioma cells, potentially providing insights into tumor metabolism in future studies. 10.1002/mrm.70430 http://creativecommons.org/licenses/by/4.0/ |
| title | Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T |
| topic | Magnetic Resonance in Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1002/mrm.70430 |