Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artículo Open Access |
| Publicado: |
Wiley
2026
|
| Materias: | |
| Acceso en línea: | https://onlinelibrary.wiley.com/doi/10.1002/mrm.70430 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Tabla de Contenidos:
- Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T Dinesh K. Deelchand Francesca Branzoli Jamie D. Walls Lucia Nichelli Marc Sanson Bertrand Mathon Małgorzata Marjańska Magnetic Resonance in Medicine ABSTRACT Purpose Cystathionine (Cth) has emerged as a promising biomarker for identifying 1p/19q codeleted gliomas. However, little is known about the T 2 relaxation time constant of Cth in gliomas. The aim of this study was to measure the T 2 of Cth in vivo in glioma and compare it to the T 2 s of other metabolites at 3 T. Methods Ten participants with glioma were scanned at 3 T. Single‐voxel proton PRESS spectra were acquired at four echo‐times to determine the T 2 relaxation time constants of Cth, N ‐acetylaspartate, scyllo ‐inositol, total creatine, and total choline. Processed spectra were analyzed using LCModel, and the results were fitted using a mono‐exponential function to estimate the T 2 relaxation time constants. T 2 of Cth was also measured using high‐resolution NMR. Results The T 2 of Cth varied across participants (42–128 ms, with a mean and standard deviation of 75 ± 24 ms). Additionally, T 2 relaxation time constants of Cth were shorter than those of singlets measured in glioma in the same participants. Distinct differences in T 2 between the CH and CH 2 proton groups in Cth were also observed both in vitro and in vivo. Conclusion Knowledge of the T 2 of Cth should improve its quantification and may help increase understanding of the intracellular environment in glioma cells, potentially providing insights into tumor metabolism in future studies. 10.1002/mrm.70430 http://creativecommons.org/licenses/by/4.0/