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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/oby.23988 |
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Table of Contents:
- Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity Talyia M. Fordham Nazeen S. Morelli Yesenia Garcia‐Reyes Meredith A. Ware Haseeb Rahat Divya Sundararajan Kelly N. Z. Fuller Cameron Severn Laura Pyle Craig R. Malloy Eunsook S. Jin Elizabeth J. Parks Robert R. Wolfe Melanie G. Cree Obesity AbstractObjectivePolycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study's objective was to determine whether supplementation would decrease HS in PCOS.MethodsA randomized, double‐blind, crossover, placebo‐controlled trial was conducted in 21 adolescents with PCOS (BMI 37.3 ± 6.5 kg/m2, age 15.6 ± 1.3 years). Liver fat, very low‐density lipoprotein (VLDL) lipogenesis, and triacylglycerol (TG) metabolism were measured following each 28‐day phase of placebo or EAA.ResultsCompared to placebo, EAA was associated with no difference in body weight (p = 0.673). Two markers of liver health improved: HS was lower (−0.8% absolute, −7.5% relative reduction, p = 0.013), as was plasma aspartate aminotransferase (AST) (−8%, p = 0.004). Plasma TG (−9%, p = 0.015) and VLDL‐TG (−21%, p = 0.031) were reduced as well. VLDL‐TG palmitate derived from lipogenesis was not different between the phases, nor was insulin sensitivity (p > 0.400 for both). Surprisingly, during the EAA phase, participants reported consuming fewer carbohydrates (p = 0.038) and total sugars (p = 0.046).ConclusionsSimilar to studies in older adults, short‐term EAA supplementation in adolescents resulted in significantly lower liver fat, AST, and plasma lipids and thus may prove to be an effective treatment in this population. Additional research is needed to elucidate the mechanisms for these effects. 10.1002/oby.23988 http://creativecommons.org/licenses/by-nc/4.0/